Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11175604 | 0.83 | L3MBTL1 (0.57) | MAPTTSHRMAPK1L3MBTL1NPC1 | |
| SCHEMBL11156637 | 0.83 | MAPT (0.41) | MAPTTSHRMAPK1L3MBTL1NPC1 | |
| SCHEMBL11174901 | 0.82 | L3MBTL1 (0.48) | MAPTTSHRMAPK1L3MBTL1NPC1 | |
| SCHEMBL11357489 | 0.78 | HDAC8 (0.56) | MAPTTSHRMAPK1L3MBTL1NPC1 | |
| SCHEMBL11180123 | 0.74 | L3MBTL1 (0.54) | MAPTTSHRL3MBTL1NPC1RAB9A | |
| SCHEMBL11180901 | 0.71 | MEN1 (0.40) | MAPTL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11177194 | 0.69 | L3MBTL1 (0.46) | MAPTTSHRMAPK1L3MBTL1NPC1 | |
| SCHEMBL11167106 | 0.69 | L3MBTL1 (0.46) | MAPTTSHRMAPK1L3MBTL1NPC1 | |
| SCHEMBL11351553 | 0.65 | L3MBTL1 (0.64) | MAPTTSHRMAPK1L3MBTL1NPC1 | |
| SCHEMBL2069336 | 0.64 | NPC1 (0.64) | MAPTTSHRMAPK1L3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007529-B1 | ANTIPROTOZOAL OXADIAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-07-20 | — | — | EP | claimed |
| US-4294842-A | MALARIA | BURROUGHS WELLCOME CO. (US) | 1981-10-13 | — | — | US | claimed |
| EP-0007529-A1 | Antiprotozoal oxadiazole derivatives, processes for their preparation and pharmaceutical formulations containing them | THE WELLCOME FOUNDATION LIMITED (GB) | 1980-02-06 | — | — | EP | claimed |
| EP-0007529-B1 | ANTIPROTOZOAL OXADIAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-07-20 | — | — | EP | disclosed |
| US-4294842-A | MALARIA | BURROUGHS WELLCOME CO. (US) | 1981-10-13 | — | — | US | disclosed |
| EP-0007529-A1 | Antiprotozoal oxadiazole derivatives, processes for their preparation and pharmaceutical formulations containing them | THE WELLCOME FOUNDATION LIMITED (GB) | 1980-02-06 | — | — | EP | disclosed |