Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 2/20 | 0.71 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.71 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.71 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.71 |
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.71 |
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.71 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.71 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.71 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.71 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.71 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.71 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.71 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.71 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.71 |
| ▸ | AGTR1 known ✓ | P30556 | 1/20 | 0.71 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.71 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.71 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.71 |
| ▸ | GHSR known ✓ | Q92847 | 1/20 | 0.71 |
| ▸ | HTR7 known ✓ | P34969 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL11200625 | 1.00 | P2RX7 (0.81) | P2RX7ADORA3CHRM1SLC6A4ADRA1A | |
| SCHEMBL1152790 | 0.99 | P2RX7 (0.83) | P2RX7ADORA3CHRM1SLC6A4ADRA1A | |
| SCHEMBL1152077 | 0.97 | P2RX7 (0.87) | P2RX7ADORA3CHRM1SLC6A4ADRA1A | |
| Hydrochloric Acid SCHEMBL11374610 | 0.93 | P2RX7 (0.80) | P2RX7ADORA3CHRM1SLC6A4ADRA1A | |
| SCHEMBL1152607 | 0.92 | P2RX7 (0.83) | P2RX7ADORA3CHRM1SLC6A4ADRA1A | |
| SCHEMBL1152704 | 0.92 | P2RX7 (0.83) | P2RX7ADORA3CHRM1SLC6A4ADRA1A | |
| Hydrochloric Acid SCHEMBL11195570 | 0.92 | P2RX7 (0.80) | P2RX7ADORA3CHRM1SLC6A4ADRA1A | |
| SCHEMBL1152747 | 0.91 | P2RX7 (0.84) | P2RX7ADORA3CHRM1SLC6A4ADRA1A | |
| Hydrochloric Acid SCHEMBL11205596 | 0.91 | P2RX7 (0.82) | P2RX7ADORA3CHRM1SLC6A4ADRA1A | |
| SCHEMBL15346498 | 0.91 | P2RX7 (0.84) | P2RX7ADORA3CHRM1SLC6A4ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4377578-A | ANTIANAPHYLACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1983-03-22 | — | — | US | disclosed |
| US-4250176-A | BENZIMIDAZOLE-2-ONE, BENZOTHIAZOL-2-ONE, OR BENZOXAZOL-2-ONE SUBSTITUTIONS, ANTIANAPHALACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-02-10 | — | — | US | disclosed |
| US-4200641-A | ANTIANAPHYLACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1980-04-29 | — | — | US | disclosed |