Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | STK25 | O00506 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1205789 | 0.84 | HPGD (0.46) | HPGDTSHRGFERATMSMN1; SMN2 | |
| SCHEMBL30442982 | 0.84 | ALOX15 (0.43) | HPGDATMTP53ALOX15MAPK1 | |
| SCHEMBL20108 | 0.84 | ALOX15 (0.43) | HPGDATMTP53ALOX15MAPK1 | |
| SCHEMBL22327730 | 0.83 | HPGD (0.44) | HPGDTSHRTP53ALOX15MAPK1 | |
| Lithium SCHEMBL31258223 | 0.82 | ALOX15 (0.42) | HPGDATMTP53ALOX15MAPK1 | |
| SCHEMBL1529233 | 0.82 | ALOX15 (0.42) | HPGDATMTP53ALOX15MAPK1 | |
| SCHEMBL28965148 | 0.82 | HPGD (0.44) | HPGDTSHRGFERATMSMN1; SMN2 | |
| SCHEMBL28959340 | 0.82 | HPGD (0.44) | HPGDTSHRGFERATMSMN1; SMN2 | |
| SCHEMBL15271218 | 0.78 | MCL1 (0.45) | HPGDTP53ALOX15MAPK1HSD17B10 | |
| SCHEMBL1120133 | 0.75 | MCL1 (0.42) | HPGDTSHRTP53ALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295115-A1 | SUBSTITUTED ISOQUINOLINYLMETHYL AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORP (CA) | 2023-09-21 | — | — | US | disclosed |
| US-20230295166-A1 | ATR INHIBITORS AND USES THEREOF | ANTENGENE DISCOVERY LIMITED (CN) | 2023-09-21 | — | — | US | disclosed |
| CN-116678907-A | Application of pyrazole ring trinuclear silver (I) complex in determination of organic molecular structure | 暨南大学 | 2023-09-01 | — | — | CN | disclosed |
| WO-2023078271-A1 | AROMATIC COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATE THEREOF, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | 上海旭成医药科技有限公司 | 2023-05-11 | — | — | WO | disclosed |
| US-20230055237-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB, LLC | 2023-02-23 | — | — | US | disclosed |
| US-20210395225-A1 | FUNCTIONALIZED AMINOTRIAZINES | LEADXPRO AG (CH) | 2021-12-23 | — | — | US | disclosed |
| EP-3495360-A1 | HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2019-06-12 | — | — | EP | disclosed |
| US-20190048020-A1 | DEUTERIUM-MODIFIED CFTR MODULATORS | CONCERT PHARMACEUTICALS, INC. | 2019-02-14 | — | — | US | disclosed |
| US-9926302-B2 | Heteroaryl substituted heterocyclyl sulfones | Grünenthal GmbH (DE) | 2018-03-27 | — | — | US | disclosed |
| US-9879000-B2 | Heteroaryl substituted heterocyclyl sulfones | Grünenthal GmbH (DE) | 2018-01-30 | — | — | US | disclosed |
| US-7157464-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-7157464-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2007-01-02 | — | — | US | disclosed |
| EP-1691810-A1 | SUBSTITUTED PIPERAZINES | ChemoCentryx Inc (US) | 2006-08-23 | — | — | EP | disclosed |
| US-20060106218-A1 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2006-05-18 | — | — | US | disclosed |
| US-20050256130-A1 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2005-11-17 | — | — | US | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |
| EP-1531822-A1 | 1-ARYL-4-SUBSTITUTED PIPERAZINE DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS | Chemocentryx, Inc. (US) | 2005-05-25 | — | — | EP | disclosed |
| US-20040162282-A1 | Substituted piperazines | CHEMOCENTRYX, INC. | 2004-08-19 | — | — | US | disclosed |
| US-20040082571-A1 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2004-04-29 | — | — | US | disclosed |
| WO-2003105853-A1 | 1-ARYL-4-SUBSTITUTED PIPERAZINES DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS | CHEMOCENTRYX, INC. (US) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210395225-A1 | FUNCTIONALIZED AMINOTRIAZINES | TBXA2R, ADORA2B, ADORA2A | HPGD 1150/4885TSHR 105/4885GFER 474/4885 |
| US-20040082571-A1 | Substituted piperazines | CCR1, CCR3, CCRL2 | HPGD 2236/4885TSHR 2351/4885GFER 4501/4885 |
| US-20230295115-A1 | SUBSTITUTED ISOQUINOLINYLMETHYL AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | HCCS, HAVCR2, HDGF | HPGD 506/4885TSHR 3955/4885GFER 2515/4885 |
| US-20060106218-A1 | Substituted piperazines | CCR1, CCR3, CCRL2 | HPGD 1705/4885TSHR 2545/4885GFER 4570/4885 |
| US-20230295166-A1 | ATR INHIBITORS AND USES THEREOF | ATR, CHEK1, CHEK2 | HPGD 3476/4885TSHR 3236/4885GFER 4563/4885 |
| US-20050256130-A1 | Substituted piperazines | CCR1, CCR3, CCRL2 | HPGD 1705/4885TSHR 2545/4885GFER 4570/4885 |
| US-20040162282-A1 | Substituted piperazines | CCR1, CCR3, CCRL2 | HPGD 2236/4885TSHR 2351/4885GFER 4501/4885 |
| US-20230055237-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | CFTR, MPST, CRAT | HPGD 538/4885TSHR 4330/4885GFER 1537/4885 |
| US-20190048020-A1 | DEUTERIUM-MODIFIED CFTR MODULATORS | CFTR, PKD2, PKD1 | HPGD 251/4885TSHR 886/4885GFER 1436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.