Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11209556 | 0.89 | NFKB1 (0.38) | NFKB1TSHRCYP2C19FFAR4FFAR1 | |
| SCHEMBL5083427 | 0.80 | TSHR (0.32) | NFKB1TSHRCYP2C19 | |
| SCHEMBL9839237 | 0.78 | S1PR1 (0.33) | NFKB1TSHRCYP2C19 | |
| SCHEMBL8002541 | 0.77 | USP2 (0.39) | NFKB1TSHRCYP2C19 | |
| SCHEMBL11258797 | 0.76 | GNAI3 (0.35) | TSHR | |
| SCHEMBL10170224 | 0.76 | GNAI3 (0.35) | TSHR | |
| SCHEMBL7993218 | 0.76 | GNAI3 (0.35) | TSHR | |
| SCHEMBL8585081 | 0.76 | GNAI3 (0.35) | TSHR | |
| SCHEMBL10434924 | 0.76 | PTGER4 (0.33) | FFAR4FFAR1 | |
| SCHEMBL10434925 | 0.74 | TSHR (0.33) | NFKB1TSHRCYP2C19FFAR4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE31343-E | STABILIZERS FOR POLYMERS | CIBA-GEIGY CORPORATION (US) | 1983-08-09 | — | — | US | disclosed |
| US-RE31342-E | STABILIZERS FOR POLYMERS | CIBA-GEIGY CORPORATION (US) | 1983-08-09 | — | — | US | disclosed |