Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 2/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | OXTR | P30559 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11227200 | 0.86 | ENPP1 (0.37) | CCR4ENPP1MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL11222396 | 0.84 | NPC1 (0.37) | CCR4L3MBTL1PDE4DPDE4BSMN1; SMN2 | |
| SCHEMBL11223761 | 0.84 | SIRT6 (0.33) | CCR4KMT2AMAPTALDH1A1RECQL | |
| SCHEMBL27895340 | 0.76 | CACNA2D1 (0.37) | CCR4MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL29299460 | 0.72 | ALDH1A1 (0.33) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL11222083 | 0.72 | POLB (0.36) | CCR4KMT2AMAPTALDH1A1RECQL | |
| SCHEMBL6056960 | 0.72 | KDM4E (0.35) | CCR4MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL6056988 | 0.72 | ALDH1A1 (0.36) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL35211616 | 0.71 | CHRNB2 (0.33) | CCR4ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL11227313 | 0.70 | LMNA (0.33) | MEN1KMT2ALMNAOXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4343802-A | ADRENERGIC BLOCKING, ANTIARRYHYTHMIA, AND CARDIOTONIC AGENTS | MERCK, SHARP & DOHME (I.A.) CORP. (US) | 1982-08-10 | — | — | US | disclosed |
| US-4193995-A | B-ADRENERGIC BLOCKING AGENTS | MERCK SHARP & DOHME (I.A.) CORP. (US) | 1980-03-18 | — | — | US | disclosed |
| US-4042586-A | ADRENERGIC BLOCKING AGENTS | MERCK SHARP & DOHME (I.A.) CORPORATION (US) | 1977-08-16 | — | — | US | disclosed |
| US-3946009-A | ADRENERGIC BLOCKING AGENTS | MERCK SHARP & DOHME (I.A.) CORPORATION (US) | 1976-03-23 | — | — | US | disclosed |