Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.31 |
| ▸ | AGXT | P21549 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.31 |
| ▸ | OXTR | P30559 | 1/20 | 0.30 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6056960 | 0.83 | KDM4E (0.35) | PDCD1CD274MEN1KMT2ASIRT6 | |
| SCHEMBL6056988 | 0.83 | ALDH1A1 (0.36) | PDCD1CD274MEN1KMT2ASIRT6 | |
| SCHEMBL29299460 | 0.72 | ALDH1A1 (0.33) | MEN1KMT2ASIRT6 | |
| SCHEMBL11223761 | 0.72 | SIRT6 (0.33) | PDCD1CD274PDE10AOXTRKMT2A | |
| SCHEMBL35211616 | 0.71 | CHRNB2 (0.33) | SIRT6 | |
| SCHEMBL11216401 | 0.70 | CCR4 (0.35) | LMNAOXTRMEN1KMT2A | |
| SCHEMBL22971348 | 0.70 | HDAC1 (0.34) | LMNAS1PR4 | |
| SCHEMBL11222083 | 0.68 | POLB (0.36) | PDCD1CD274KMT2ASIRT6 | |
| SCHEMBL27677660 | 0.68 | NNMT (0.35) | MEN1KMT2ASIRT6 | |
| SCHEMBL6056985 | 0.68 | PDCD1 (0.38) | PDCD1CD274MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4343802-A | ADRENERGIC BLOCKING, ANTIARRYHYTHMIA, AND CARDIOTONIC AGENTS | MERCK, SHARP & DOHME (I.A.) CORP. (US) | 1982-08-10 | — | — | US | disclosed |
| US-4193995-A | B-ADRENERGIC BLOCKING AGENTS | MERCK SHARP & DOHME (I.A.) CORP. (US) | 1980-03-18 | — | — | US | disclosed |
| US-4042586-A | ADRENERGIC BLOCKING AGENTS | MERCK SHARP & DOHME (I.A.) CORPORATION (US) | 1977-08-16 | — | — | US | disclosed |
| US-3946009-A | ADRENERGIC BLOCKING AGENTS | MERCK SHARP & DOHME (I.A.) CORPORATION (US) | 1976-03-23 | — | — | US | disclosed |