Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 6/20 | 0.85 |
| ▸ | HTR1A | P08908 | 6/20 | 0.63 |
| ▸ | HTR2A | P28223 | 5/20 | 0.63 |
| ▸ | HTR2C | P28335 | 5/20 | 0.63 |
| ▸ | MPO | P05164 | 1/20 | 0.63 |
| ▸ | HTR1D | P28221 | 9/20 | 0.62 |
| ▸ | HTR1B | P28222 | 7/20 | 0.62 |
| ▸ | HTR2B | P41595 | 4/20 | 0.60 |
| ▸ | HTR7 | P34969 | 4/20 | 0.60 |
| ▸ | HTR5A | P47898 | 4/20 | 0.60 |
| ▸ | HTR1E | P28566 | 3/20 | 0.60 |
| ▸ | HTR1F | P30939 | 3/20 | 0.60 |
| ▸ | HTR3A | P46098 | 3/20 | 0.60 |
| ▸ | HTR6 | P50406 | 3/20 | 0.60 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.60 |
| ▸ | HTR3B | O95264 | 2/20 | 0.60 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.60 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.60 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24243716 | 0.88 | SLC6A4 (0.70) | SLC6A4HTR1AHTR2AMPOHTR1D | |
| SCHEMBL11354043 | 0.86 | SLC6A4 (0.68) | SLC6A4HTR1AHTR2AMPOHTR1D | |
| SCHEMBL4358526 | 0.85 | SLC6A4 (0.71) | SLC6A4CYP2D6 | |
| SCHEMBL24243731 | 0.84 | HTR2A (0.69) | SLC6A4HTR1AHTR2AMPOHTR1D | |
| SCHEMBL12881233 | 0.84 | SLC6A4 (0.68) | SLC6A4HTR1A | |
| SCHEMBL9830738 | 0.82 | HTR6 (0.67) | SLC6A4HTR1DHTR6 | |
| SCHEMBL3103741 | 0.81 | SLC6A4 (0.73) | SLC6A4HTR1A | |
| SCHEMBL25244606 | 0.81 | SLC6A4 (0.64) | SLC6A4 | |
| SCHEMBL2531600 | 0.81 | SLC6A4 (0.64) | SLC6A4HTR1AHTR2AHTR2CMPO | |
| SCHEMBL8136598 | 0.81 | SLC6A4 (0.64) | SLC6A4HTR2CCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572647-B1 | SYNTHESIS OF AMINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | BASF SE (DE) | 2016-09-21 | — | — | EP | disclosed |
| EP-1572647-B1 | SYNTHESIS OF AMINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | BASF SE (DE) | 2016-09-21 | — | — | EP | disclosed |
| CN-101247853-B | Substituted indole compounds having NOS inhibitory activity | NEURAXON INC | 2014-11-12 | — | — | CN | disclosed |
| US-8822702-B2 | Synthesis of amines and intermediates for the synthesis thereof | BASF SE (DE) | 2014-09-02 | — | — | US | disclosed |
| US-8822702-B2 | Synthesis of amines and intermediates for the synthesis thereof | BASF SE (DE) | 2014-09-02 | — | — | US | disclosed |
| US-8822702-B2 | Synthesis of amines and intermediates for the synthesis thereof | BASF SE (DE) | 2014-09-02 | — | — | US | disclosed |
| US-8710093-B2 | Synthesis of amines and intermediates for the synthesis thereof | BASF SE Ludwigshafen (DE) | 2014-04-29 | — | — | US | disclosed |
| US-20140051687-A1 | SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2014-02-20 | — | — | US | disclosed |
| US-20140051687-A1 | SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2014-02-20 | — | — | US | disclosed |
| EP-2666772-A1 | Synthesis of amines and intermediates for the synthesis thereof | BASF SE (DE) | 2013-11-27 | — | — | EP | disclosed |
| WO-2005075422-A1 | SYNTHESIS METHODS AND INTERMEDIATES FOR THE MANUFACTURE OF RIZATRIPTAN | RATIOPHARM GMBH (DE) | 2005-08-18 | — | — | WO | disclosed |
| WO-2004056769-A2 | SYNTHESIS OF AMINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2004-07-08 | — | — | WO | disclosed |
| US-6187805-B1 | TREATING CONDITION FOR WHICH SELECTIVE AGONISM OR ANTAGONISM OF 5-HT-6 RECEPTORS IS INDICATED BY ADMINISTERING COMPOUNDS SUCH AS N,N-DIMETHYL 2-(1-(BENZENESULPHONYL)-5-METHOXY-1H-INDOL-3-YL)ETHYLAMINE | MERCK SHARP & DOHME LTD. (GB) | 2001-02-13 | — | — | US | disclosed |
| EP-0637307-B1 | IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 2000-11-08 | — | — | EP | disclosed |
| EP-0637307-A1 | IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1995-02-08 | — | — | EP | disclosed |
| WO-1993020066-A1 | IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1993-10-14 | — | — | WO | disclosed |
| EP-0225726-B1 | INDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1991-04-17 | — | — | EP | disclosed |
| US-4833153-A | VASOCONSTRICTORS, MIGRAINES | GLAXO GROUP LIMITED (GB) | 1989-05-23 | — | — | US | disclosed |
| EP-0225726-A1 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1987-06-16 | — | — | EP | disclosed |
| US-4252803-A | HYPOTENSIVE AGENTS, ANALGESICS | GLAXO GROUP LIMITED (GB) | 1981-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051687-A1 | SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NOS2, NOS1, NOS3 | SLC6A4 215/4885HTR1A 91/4885HTR2A 156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.