Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.56 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.50 |
| ▸ | WNT3A | P56704 | 3/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 3/20 | 0.45 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11221344 | 0.88 | TPSAB1 (0.48) | TPSAB1CTNNB1WNT3ACHRM4ADAM17 | |
| SCHEMBL11223398 | 0.86 | ADAM17 (0.57) | TPSAB1CTNNB1WNT3AADAM17AVPR1A | |
| SCHEMBL11312535 | 0.86 | AVPR1A (0.56) | TPSAB1CTNNB1WNT3AADAM17CCR2 | |
| SCHEMBL11224818 | 0.84 | ALDH1A1 (0.59) | TPSAB1NPSR1DRD2LMNATP53 | |
| SCHEMBL11314928 | 0.82 | KMT2A (0.50) | TPSAB1CTNNB1WNT3AADAM17AVPR1A | |
| SCHEMBL11221666 | 0.81 | KDM1A (0.54) | TPSAB1CTNNB1WNT3AADAM17AVPR1A | |
| SCHEMBL11321191 | 0.81 | AVPR1A (0.56) | TPSAB1CTNNB1WNT3AADAM17AVPR1A | |
| SCHEMBL11311849 | 0.81 | ADAM17 (0.50) | TPSAB1CTNNB1WNT3AADAM17AVPR1A | |
| SCHEMBL11311419 | 0.81 | ADAM17 (0.50) | TPSAB1CTNNB1WNT3AADAM17AVPR1A | |
| SCHEMBL11349798 | 0.79 | TPSAB1 (0.47) | TPSAB1CTNNB1WNT3AAVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007399-B1 | INDOLYLALKYL AMINES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR MANUFACTURE | MERCK PATENT GmbH (DE) | 1982-01-20 | — | — | EP | disclosed |
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |
| EP-0007399-A1 | Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture | MERCK PATENT GmbH (DE) | 1980-02-06 | — | — | EP | disclosed |