Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 4/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11223978 | 0.88 | TPSAB1 (0.56) | TPSAB1AVPR1ACCR2CTNNB1WNT3A | |
| SCHEMBL11247565 | 0.87 | ALDH1A1 (0.51) | TPSAB1AVPR1AADAMTS5ESR1PARP1 | |
| SCHEMBL11223947 | 0.85 | AVPR1A (0.62) | TPSAB1AVPR1AESR1PARP1DRD2 | |
| SCHEMBL11251234 | 0.85 | AVPR1A (0.49) | TPSAB1AVPR1ACTNNB1WNT3AADAMTS5 | |
| SCHEMBL11229177 | 0.85 | TPSAB1 (0.56) | TPSAB1AVPR1ACTNNB1WNT3AESR1 | |
| SCHEMBL11223398 | 0.85 | ADAM17 (0.57) | TPSAB1AVPR1ACTNNB1WNT3AESR1 | |
| SCHEMBL11331493 | 0.84 | ALDH1A1 (0.53) | TPSAB1ESR1PARP1SOS1 | |
| SCHEMBL11230105 | 0.84 | AVPR1A (0.48) | TPSAB1AVPR1A | |
| SCHEMBL11251330 | 0.83 | SMN1; SMN2 (0.56) | — | |
| SCHEMBL11233891 | 0.83 | AVPR1A (0.47) | TPSAB1AVPR1AESR1PARP1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007399-B1 | INDOLYLALKYL AMINES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR MANUFACTURE | MERCK PATENT GmbH (DE) | 1982-01-20 | — | — | EP | disclosed |
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |
| EP-0007399-A1 | Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture | MERCK PATENT GmbH (DE) | 1980-02-06 | — | — | EP | disclosed |