Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | WNT3A | P56704 | 1/20 | 0.47 |
| ▸ | RBP4 | P02753 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HAT1 | O14929 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11244938 | 0.85 | TPSAB1 (0.55) | TPSAB1CTNNB1WNT3APARP1ADAMTS5 | |
| SCHEMBL11334889 | 0.84 | ALDH1A1 (0.48) | TPSAB1RBP4PARP1ADAMTS5ESR1 | |
| SCHEMBL11250198 | 0.83 | PARP1 (0.44) | TPSAB1PARP1ADAMTS5ESR1AVPR1A | |
| SCHEMBL11251854 | 0.82 | RBP4 (0.41) | TPSAB1RBP4PARP1ADAMTS5ESR1 | |
| SCHEMBL11223398 | 0.81 | ADAM17 (0.57) | TPSAB1CTNNB1WNT3APARP1ESR1 | |
| SCHEMBL11221344 | 0.80 | TPSAB1 (0.48) | TPSAB1CTNNB1WNT3APARP1ADAMTS5 | |
| SCHEMBL11223978 | 0.79 | TPSAB1 (0.56) | TPSAB1CTNNB1WNT3AAVPR1A | |
| SCHEMBL11227630 | 0.78 | AVPR1A (0.49) | TPSAB1PARP1ADAMTS5ESR1AVPR1A | |
| SCHEMBL11234418 | 0.78 | TPSAB1 (0.46) | TPSAB1PARP1ADAMTS5ESR1AVPR1A | |
| SCHEMBL11232216 | 0.78 | AVPR1A (0.51) | PARP1ADAMTS5ESR1AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |
| EP-0007399-A1 | Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture | MERCK PATENT GmbH (DE) | 1980-02-06 | — | — | EP | disclosed |