SCHEMBL11224124

SCHEMBL11224124

Nc1ccc(-c2cc(Cl)ccc2S(=O)(=O)c2ccc(Cl)cc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.61
KMT2A Q03164 1/20 0.61
PRMT1 Q99873 2/20 0.51
CYP3A4 P08684 2/20 0.46
ALDH1A1 P00352 2/20 0.46
HTR6 P50406 2/20 0.46
MAPK1 P28482 1/20 0.46
LMNA P02545 1/20 0.46
MPO P05164 1/20 0.46
CYP2C9 P11712 1/20 0.46
TSHR P16473 1/20 0.46
PTGS2 P35354 2/20 0.45
PTGS1 P23219 1/20 0.45
PPARG P37231 1/20 0.44
POLB P06746 1/20 0.43
KIF18A Q8NI77 1/20 0.42
HKDC1 Q2TB90 1/20 0.42
PKM P14618 1/20 0.41
CNR2 P34972 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2019763 0.84 KIF18A (0.55) KMT2ACYP3A4ALDH1A1HTR6MAPK1
SCHEMBL10977080 0.83 S100A4 (0.45) MEN1KMT2ACYP3A4ALDH1A1MAPK1
SCHEMBL11214449 0.80 MEN1 (0.63) MEN1KMT2APRMT1CYP3A4ALDH1A1
SCHEMBL2762404 0.77 MEN1 (1.00) MEN1KMT2APRMT1CYP3A4ALDH1A1
SCHEMBL10972692 0.77 MEN1 (0.63) MEN1KMT2APRMT1CYP3A4ALDH1A1
SCHEMBL10656611 0.77 MEN1 (0.63) MEN1KMT2APRMT1CYP3A4ALDH1A1
SCHEMBL5261746 0.76 MEN1 (0.57) MEN1KMT2APRMT1CYP3A4ALDH1A1
SCHEMBL6764348 0.75 ALOX5AP (0.47)
SCHEMBL17774688 0.73 MEN1 (0.63) MEN1KMT2APRMT1CYP3A4ALDH1A1
SCHEMBL3671582 0.73 PTGS2 (0.46) PTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-58055006-A None JP disclosed
JP-S5855006-A POLYSULFONE ETHER AMIDE MEMBRANE MITSUBISHI CHEM IND LTD 1983-04-01 JP disclosed