Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAPDH | P04406 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19014491 | 0.74 | KMT2A (0.41) | ATMRAB9ANPC1GAPDHPOLB | |
| SCHEMBL11615383 | 0.72 | ATM (0.47) | ATMRAB9ANPC1GAPDHPOLB | |
| SCHEMBL1123002 | 0.70 | MMP13 (0.33) | SMN1; SMN2ALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL831034 | 0.67 | HPGD (0.51) | ALDH1A1KMT2AMEN1LMNAHPGD | |
| SCHEMBL19890349 | 0.66 | RAB9A (0.38) | ATMRAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL10548969 | 0.66 | BRD4 (0.35) | ATMRAB9ANPC1GAPDHPOLB | |
| SCHEMBL1122298 | 0.65 | CA2 (0.52) | POLBSMN1; SMN2ALDH1A1GAAKMT2A | |
| SCHEMBL9912435 | 0.65 | GAPDH (0.58) | ATMRAB9ANPC1GAPDHPOLB | |
| SCHEMBL1256322 | 0.63 | — | — | |
| SCHEMBL6666845 | 0.63 | ATM (0.40) | ATMRAB9ANPC1GAPDHPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379508-B9 | N-(ARYL)-2-ARYLETHENESULFONAMIDES AND THERAPEUTIC USES THEREOF | UNIV TEMPLE (US) | 2011-02-09 | — | — | EP | disclosed |
| EP-1379508-B1 | N-(ARYL)-2-ARYLETHENESULFONAMIDES AND THERAPEUTIC USES THEREOF | UNIV TEMPLE (US) | 2010-09-01 | — | — | EP | disclosed |
| US-6646009-B2 | Use against proliferative disorders including cancer, and as a radioprotective compound for normal cells from ionizing radiation | Temple University — Of Commonwealth System of Higher Education | 2003-11-11 | — | — | US | disclosed |