Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11219877 | 0.90 | DRD2 (0.52) | DRD2DRD3 | |
| SCHEMBL11226328 | 0.84 | KDM4E (0.57) | DRD2DRD3ADRA1AHTR1AKDM4E | |
| SCHEMBL10959130 | 0.84 | JAK2 (0.56) | DRD2DRD3PDE2AOPRM1OPRK1 | |
| SCHEMBL14027792 | 0.78 | HTR1A (0.47) | ADRA1AHTR1A | |
| SCHEMBL8995183 | 0.77 | HTR1A (0.48) | ADRA1AHTR1AADRA1D | |
| SCHEMBL17429447 | 0.75 | HTR1A (0.51) | ADRA1AHTR1A | |
| SCHEMBL3682166 | 0.75 | KDM4E (0.55) | ADRA1AHTR1AKDM4EATMADRA1D | |
| SCHEMBL11065117 | 0.74 | BTK (0.45) | ADRA1AHTR1AKDM4E | |
| SCHEMBL19210848 | 0.74 | KDM4E (0.70) | KDM4EATMADRA1DCYP2D6 | |
| SCHEMBL18089303 | 0.72 | DRD2 (0.48) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4332808-A | Dopaminergically stimulating 4-substituted indoles | ROUSSEL UCLAF (FR) | 1982-06-01 | — | — | US | claimed |
| US-4332808-A | Dopaminergically stimulating 4-substituted indoles | ROUSSEL UCLAF (FR) | 1982-06-01 | — | — | US | disclosed |