Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.39 |
| ▸ | GOT1 | P17174 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11068236 | 0.79 | HPGDS (0.43) | BTKHPGDSMTNR1AMTNR1BPROKR1 | |
| SCHEMBL11226328 | 0.76 | KDM4E (0.57) | ADRA1AHTR1AKDM4E | |
| SCHEMBL9671400 | 0.75 | RBP4 (0.48) | HPGDSRBP4PROKR1 | |
| SCHEMBL11226286 | 0.74 | DRD2 (0.44) | ADRA1AHTR1AKDM4E | |
| SCHEMBL16446718 | 0.74 | PROKR1 (0.54) | HPGDSADRA1ARBP4PROKR1 | |
| SCHEMBL14027792 | 0.73 | HTR1A (0.47) | ADRA1AJAK2JAK1JAK3HTR1A | |
| SCHEMBL11219877 | 0.72 | DRD2 (0.52) | — | |
| SCHEMBL8995183 | 0.72 | HTR1A (0.48) | ADRA1AJAK2JAK1TYK2JAK3 | |
| SCHEMBL10959130 | 0.71 | JAK2 (0.56) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL9671327 | 0.71 | HPGDS (0.44) | HPGDSRBP4ALDH1A1PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4435408-A | Dopaminergic stimulating and antianoxic 4-substituted 2H-indole-2-ones | ROUSSEL UCLAF (FR) | 1984-03-06 | — | — | US | disclosed |