Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 1/20 | 0.47 |
| ▸ | HAT1 | O14929 | 2/20 | 0.45 |
| ▸ | EP300 | Q09472 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | CBX7 | O95931 | 1/20 | 0.43 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.43 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.43 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.43 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.43 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11247565 | 0.85 | ALDH1A1 (0.51) | AVPR1ADRD2DRD4DRD3TPSAB1 | |
| SCHEMBL11251234 | 0.85 | AVPR1A (0.49) | AVPR1ADRD2DRD4DRD3TPSAB1 | |
| SCHEMBL11229177 | 0.85 | TPSAB1 (0.56) | AVPR1ADRD2DRD4DRD3TPSAB1 | |
| SCHEMBL11223947 | 0.85 | AVPR1A (0.62) | AVPR1AHAT1EP300DRD2DRD4 | |
| SCHEMBL11223398 | 0.85 | ADAM17 (0.57) | AVPR1ADRD2DRD4DRD3TPSAB1 | |
| SCHEMBL11362100 | 0.84 | ALDH1A1 (0.53) | SLC6A4HTR1A | |
| SCHEMBL11230105 | 0.84 | AVPR1A (0.48) | AVPR1AHAT1EP300TPSAB1 | |
| SCHEMBL11251330 | 0.83 | SMN1; SMN2 (0.56) | — | |
| SCHEMBL11221344 | 0.83 | TPSAB1 (0.48) | AVPR1ADRD2DRD4DRD3TPSAB1 | |
| SCHEMBL11251657 | 0.80 | AVPR1A (0.50) | AVPR1AESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007399-B1 | INDOLYLALKYL AMINES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR MANUFACTURE | MERCK PATENT GmbH (DE) | 1982-01-20 | — | — | EP | disclosed |
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |
| EP-0007399-A1 | Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture | MERCK PATENT GmbH (DE) | 1980-02-06 | — | — | EP | disclosed |