Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4645532 | 0.79 | TP53 (0.55) | TP53LMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL2973653 | 0.78 | LDHA (0.37) | TP53LMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL11076258 | 0.77 | TP53 (0.53) | TP53LMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL23498885 | 0.69 | TP53 (0.49) | TP53LMNAPOLBKDM4E | |
| SCHEMBL5518087 | 0.67 | ALDH1A1 (0.43) | POLBKDM4EALDH1A1MAPTPKM | |
| SCHEMBL7678717 | 0.66 | LMNA (0.57) | TP53LMNAPOLBKDM4EMAPT | |
| SCHEMBL9957515 | 0.66 | LPO (0.32) | — | |
| SCHEMBL6401221 | 0.64 | CDC25A (0.40) | KDM4EMEN1PTGS1KMT2A | |
| SCHEMBL11066272 | 0.64 | TP53 (0.51) | TP53LMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL24348223 | 0.64 | MEN1 (0.34) | LMNAKDM4EALDH1A1SLC22A12MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4363918-A | Method of preparing 1-alkyl-3-carboxy-1H pyrrole-2-acetic acids | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-12-14 | — | — | US | disclosed |