Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | RGS12 | O14924 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11243330 | 0.92 | SLC22A12 (0.45) | BCL2L1MCL1SLC22A12MAPTKDM4E | |
| SCHEMBL11232390 | 0.83 | AKR1B1 (0.53) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11244597 | 0.82 | CA2 (0.45) | BCL2L1MCL1SLC22A12MAPTKDM4E | |
| Methane SCHEMBL11248449 | 0.82 | AKR1B1 (0.51) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11242088 | 0.82 | BCKDK (0.51) | MCL1SLC22A12MAPTKDM4EALDH1A1 | |
| SCHEMBL11237206 | 0.81 | KDM4E (0.47) | SLC22A12MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL11248851 | 0.81 | AKR1C2 (0.63) | MAPTKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL11228298 | 0.81 | CA2 (0.50) | BCL2L1MCL1SLC22A12MAPTKDM4E | |
| SCHEMBL11246646 | 0.80 | CA2 (0.49) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10950169 | 0.80 | KDM4E (0.45) | SLC22A12MAPTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4334078-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATICS | HOFFMANN-LA ROCHE INC. (US) | 1982-06-08 | — | — | US | disclosed |
| US-4219657-A | USED AS ANTIINFLAMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-08-26 | — | — | US | disclosed |