Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11242747 | 0.84 | CA2 (0.45) | CA2SLC22A12KDM4EHPGDHSD17B10 | |
| SCHEMBL11239805 | 0.83 | CA2 (0.46) | CA2SLC22A12KDM4EHPGDHSD17B10 | |
| SCHEMBL11240749 | 0.82 | L3MBTL1 (0.44) | KDM4EHSD17B10ALDH1A1MAPTMEN1 | |
| SCHEMBL11228298 | 0.81 | CA2 (0.50) | CA2SLC22A12KDM4EHPGDHSD17B10 | |
| SCHEMBL11242088 | 0.79 | BCKDK (0.51) | CA2SLC22A12KDM4EHPGDHSD17B10 | |
| SCHEMBL11244597 | 0.76 | CA2 (0.45) | CA2SLC22A12KDM4EHPGDHSD17B10 | |
| SCHEMBL11240017 | 0.75 | KEAP1 (0.51) | CA2SLC22A12KDM4EHPGDHSD17B10 | |
| Methane SCHEMBL11235653 | 0.74 | KEAP1 (0.50) | CA2SLC22A12KDM4EHPGDHSD17B10 | |
| SCHEMBL11246405 | 0.74 | BCL2L1 (0.50) | SLC22A12KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL11232390 | 0.74 | AKR1B1 (0.53) | KDM4EHPGDHSD17B10ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4334078-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATICS | HOFFMANN-LA ROCHE INC. (US) | 1982-06-08 | — | — | US | disclosed |
| US-4219657-A | USED AS ANTIINFLAMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-08-26 | — | — | US | disclosed |