Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 2/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.63 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PRNP | P04156 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11246657 | 0.93 | AKR1C2 (0.58) | AKR1C2PTGS1AKR1C3KDM4EGAA | |
| SCHEMBL11246405 | 0.81 | BCL2L1 (0.50) | AKR1C2PTGS1AKR1C3KDM4EGAA | |
| SCHEMBL11232390 | 0.78 | AKR1B1 (0.53) | PTGS1KDM4EGAAALDH1A1TSHR | |
| 6-Methoxy-2-Naphthylacetic Acid SCHEMBL253759 | 0.78 | AKR1C3 (1.00) | AKR1C2PTGS1AKR1C3KDM4EGAA | |
| SCHEMBL11243330 | 0.78 | SLC22A12 (0.45) | KDM4EGAAALDH1A1TSHRMAPT | |
| SCHEMBL28654017 | 0.78 | TUBB4A (0.64) | MAPTTDP1L3MBTL1 | |
| SCHEMBL11242088 | 0.77 | BCKDK (0.51) | KDM4EGAAALDH1A1TSHRMAPT | |
| Methane SCHEMBL11248449 | 0.77 | AKR1B1 (0.51) | PTGS1KDM4EGAAALDH1A1TSHR | |
| SCHEMBL11425132 | 0.77 | PTGS1 (0.63) | AKR1C2PTGS1AKR1C3KDM4EGAA | |
| SCHEMBL11237206 | 0.77 | KDM4E (0.47) | AKR1C2PTGS1AKR1C3KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4334078-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATICS | HOFFMANN-LA ROCHE INC. (US) | 1982-06-08 | — | — | US | disclosed |
| US-4219657-A | USED AS ANTIINFLAMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-08-26 | — | — | US | disclosed |