Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11052569 | 0.89 | ALDH1A1 (0.43) | MAPTHTTALDH1A1KDM4EIDH1 | |
| SCHEMBL11053888 | 0.87 | HTT (0.47) | MAPTHTTALDH1A1LMNAPKM | |
| SCHEMBL11261823 | 0.85 | TAS2R14 (0.44) | MAPTHTTALDH1A1IDH1KMT2A | |
| SCHEMBL11263600 | 0.85 | GAA (0.48) | MAPTHTTALDH1A1LMNANPSR1 | |
| SCHEMBL11258056 | 0.85 | MEN1 (0.47) | MAPTHTTALDH1A1HPGDKDM4E | |
| SCHEMBL11054561 | 0.84 | HTT (0.50) | MAPTHTTALDH1A1KDM4ELMNA | |
| SCHEMBL11052091 | 0.82 | NPC1 (0.40) | MAPTHTTALDH1A1KDM4EPKM | |
| SCHEMBL11053772 | 0.82 | HTT (0.38) | MAPTHTTPKMMAPK1KMT2A | |
| SCHEMBL11250897 | 0.82 | PKM (0.48) | MAPTHTTPKMKMT2AMEN1 | |
| SCHEMBL11052904 | 0.82 | HTT (0.47) | HTTMAPK1NPSR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |