SCHEMBL11247290

SCHEMBL11247290

Cc1nccn1CCOc1ccc(Cl)cc1

nearest known ligand 0.84

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.55
L3MBTL1 Q9Y468 2/20 0.52
LMNA P02545 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
ALDH1A1 P00352 1/20 0.47
POLB P06746 1/20 0.47
KMT2A Q03164 1/20 0.47
KCNH2 Q12809 1/20 0.47
CYP1A2 P05177 2/20 0.47
CYP2C19 P33261 2/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP19A1 P11511 1/20 0.47
CYP2C9 P11712 1/20 0.47
NSD2 O96028 1/20 0.46
NSD3 Q9BZ95 1/20 0.46
PDE6D O43924 1/20 0.46
MAPT P10636 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11248409 0.92 ALDH1A1 (0.54) NPSR1L3MBTL1SMN1; SMN2ALDH1A1POLB
SCHEMBL11243418 0.91 ALDH1A1 (0.53) NPSR1SMN1; SMN2ALDH1A1POLBKMT2A
SCHEMBL11240131 0.84 ALDH1A1 (0.47) L3MBTL1LMNASMN1; SMN2ALDH1A1POLB
SCHEMBL11142733 0.84 TBXAS1 (0.51) L3MBTL1LMNAALDH1A1POLBKMT2A
SCHEMBL7875320 0.84 DRD4 (0.60) ALDH1A1POLBKMT2A
SCHEMBL11251413 0.84 KDM4E (0.49) LMNAALDH1A1POLBKMT2AKCNH2
SCHEMBL11241447 0.80 HPGD (0.56) LMNASMN1; SMN2ALDH1A1KCNH2
SCHEMBL8678546 0.76 KMT2A (0.60) L3MBTL1LMNASMN1; SMN2ALDH1A1POLB
SCHEMBL2950629 0.75 LMNA (0.71) L3MBTL1LMNASMN1; SMN2ALDH1A1POLB
SCHEMBL7292248 0.75 MEN1 (0.54) L3MBTL1LMNASMN1; SMN2ALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0049060-A1 Imidazoles BEECHAM GROUP PLC (GB) 1982-04-07 EP disclosed