Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLS | O94925 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11261355 | 0.84 | TDP1 (0.50) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL11257657 | 0.79 | LMNA (0.46) | SMN1; SMN2LMNAMEN1KMT2AKDM4E | |
| SCHEMBL11254420 | 0.78 | PKM (0.45) | ALDH1A1SMN1; SMN2LMNAKMT2ARECQL | |
| Formamide SCHEMBL11440222 | 0.78 | TDP1 (0.44) | ALDH1A1SMN1; SMN2CYP2C19KDM4E | |
| SCHEMBL11267468 | 0.77 | ANPEP (0.38) | ALDH1A1MEN1KMT2ACYP3A4ACHE | |
| SCHEMBL11257116 | 0.76 | KMT2A (0.39) | ALDH1A1LMNAATMMEN1KMT2A | |
| SCHEMBL11257966 | 0.76 | ROS1 (0.46) | ALDH1A1SMN1; SMN2ATMROS1RPS6KB1 | |
| SCHEMBL11250074 | 0.74 | LOXL2 (0.49) | LMNAKDM4E | |
| SCHEMBL11261342 | 0.74 | GABRA1 (0.32) | LMNAMEN1KMT2AKDM4E | |
| SCHEMBL11249938 | 0.74 | TDP1 (0.45) | ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337256-A | ANTIINFLAMMATORY AGENTS; ANTIAGGLOMERANTS; ENZYME INHIBITORS; ANTIULCER AGENTS | TEIKOKU HORMONE MANUFACTURING CO., LTD. (JP) | 1982-06-29 | — | — | US | disclosed |
| EP-0013411-A1 | Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1980-07-23 | — | — | EP | disclosed |