SCHEMBL11260189

SCHEMBL11260189

O=C1C=C(N(C2=CC(=O)NC2=O)c2ccc(Cc3ccc(N(C4=CC(=O)NC4=O)C4=CC(=O)NC4=O)cc3)cc2)C(=O)N1

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.36
CYP3A4 P08684 1/20 0.36
TSHR P16473 1/20 0.36
MAPK1 P28482 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
TGM2 P21980 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11503456 0.79 MAOA (0.34) TGM2
SCHEMBL2211488 0.76 POLB (0.41) ALDH1A1CYP3A4TSHRTDP1
SCHEMBL7540808 0.69 AR (0.33)
SCHEMBL9508340 0.69 MAOA (0.35) TGM2
SCHEMBL908235 0.68 TGM2 (0.35) ALDH1A1CYP3A4TSHRTDP1TGM2
SCHEMBL10719678 0.65
SCHEMBL9491075 0.64 USP2 (0.34) ALDH1A1
SCHEMBL30824866 0.64
SCHEMBL10480214 0.63 CALM1 (0.41)
SCHEMBL3346448 0.63 CXCR2 (0.34) ALDH1A1CYP3A4TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0001666-B1 IMIDE-CROSSLINKED ETHYLENIC POLYMER RESIN FOAMS AND METHOD OF MAKING THE DOW CHEMICAL COMPANY (US) 1982-05-05 EP disclosed
EP-0001666-A2 Imide-crosslinked ethylenic polymer resin foams and method of making THE DOW CHEMICAL COMPANY (US) 1979-05-02 EP disclosed
EP-0001666-A2 Imide-crosslinked ethylenic polymer resin foams and method of making THE DOW CHEMICAL COMPANY (US) 1979-05-02 EP disclosed
US-4105646-A α,β-Unsaturated schiff-base chain extension reactions for high temperature polymers CIBA-GEIGY CORPORATION (US) 1978-08-08 US disclosed
US-3979350-A MOLDING MATERIALS CIBA-GEIGY CORPORATION (US) 1976-09-07 US disclosed