Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | PYGL | P06737 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.40 |
| ▸ | LIPC | P11150 | 2/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11267381 | 0.88 | MAPT (0.55) | TSHRIGF1RALOX15ABCB11LMNA | |
| SCHEMBL11269559 | 0.86 | MAPT (0.43) | TSHRHDAC6ABCB11LMNAMAPT | |
| SCHEMBL11140301 | 0.86 | TMEM97 (0.39) | TSHRPYGLABCB11LMNAMAPT | |
| SCHEMBL11276627 | 0.85 | ABCB11 (0.45) | TSHRPYGLHDAC6ABCB11LMNA | |
| SCHEMBL11269045 | 0.84 | MAPT (0.57) | TSHRHDAC6IGF1RALOX15ABCB11 | |
| SCHEMBL11272940 | 0.83 | LMNA (0.58) | TSHRPYGLHDAC6IGF1RALOX15 | |
| SCHEMBL11271824 | 0.80 | ABCB11 (0.53) | TSHRPYGLHDAC6IGF1RALOX15 | |
| SCHEMBL11261351 | 0.80 | POLB (0.38) | TSHRABCB11LMNAMAPTMAPK1 | |
| SCHEMBL11210382 | 0.80 | TSHR (0.44) | TSHRPYGLHDAC6IGF1RALOX15 | |
| SCHEMBL11271674 | 0.80 | POLB (0.43) | HDAC6LMNAMAPTMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4324796-A | HYPOGLYCEMIC AGENTS, HYPOKETONEMIC AGENTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1982-04-13 | — | — | US | disclosed |