SCHEMBL11264259

SCHEMBL11264259

Clc1ccc2c(c1)nnn2-n1nnc2cc(Cl)ccc21

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHEK1 O14757 1/20 0.53
LIMK1 P53667 1/20 0.53
MAPK14 Q16539 1/20 0.53
CLK4 Q9HAZ1 1/20 0.53
KCNMA1 Q12791 2/20 0.46
FGFR1 P11362 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.40
SLC9A1 P19634 1/20 0.39
KMO O15229 1/20 0.39
F7 P08709 1/20 0.39
F3 P13726 1/20 0.39
DYRK1A Q13627 1/20 0.39
MGAM O43451 2/20 0.39
AMY1A P0DUB6 2/20 0.39
GAA P10253 2/20 0.39
SI P14410 2/20 0.39
MGAM2 Q2M2H8 2/20 0.39
CUL4A Q13619 1/20 0.39
PIK3CG P48736 1/20 0.38
KMT2A Q03164 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1133392 0.79 RAB9A (0.56) CHEK1LIMK1MAPK14CLK4KCNMA1
SCHEMBL3278710 0.79 PKM (0.56) CHEK1LIMK1MAPK14CLK4KCNMA1
SCHEMBL1150909 0.79 CHEK1 (0.50) CHEK1LIMK1MAPK14CLK4KCNMA1
SCHEMBL3676899 0.79 PKM (0.56) CHEK1LIMK1MAPK14CLK4KCNMA1
SCHEMBL11053779 0.78 CHEK1 (0.49) CHEK1LIMK1MAPK14CLK4KCNMA1
SCHEMBL13604173 0.76 SLC9A1 (0.49) CHEK1LIMK1MAPK14CLK4KCNMA1
SCHEMBL31023980 0.75 CHEK1 (0.50) CHEK1LIMK1MAPK14CLK4KCNMA1
SCHEMBL11270062 0.74 KCNMA1 (0.46) KCNMA1FGFR1MGAMAMY1AGAA
SCHEMBL10428731 0.74 KCNMA1 (0.61) CHEK1LIMK1MAPK14CLK4KCNMA1
SCHEMBL10428898 0.74 KCNMA1 (0.61) CHEK1LIMK1MAPK14CLK4KCNMA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4332884-A USING A DIOXIME CHELATING AGENT RICOH CO., LTD. (JP) 1982-06-01 US disclosed
US-4306014-A AMMONIA OR AMINES SUPPRESS THE COLOR-FORMING REACTION SYSTEM RICOH CO., LTD. (JP) 1981-12-15 US disclosed