Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.69 |
| ▸ | HTR1A | P08908 | 5/20 | 0.52 |
| ▸ | HTR2A | P28223 | 5/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 4/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11275967 | 0.97 | DRD2 (0.65) | DRD2HTR1AHTR2AKCNH2SLC6A2 | |
| SCHEMBL11275908 | 0.86 | DRD2 (0.67) | DRD2HTR1AHTR2AKCNH2SLC6A2 | |
| SCHEMBL11266439 | 0.85 | DRD2 (0.67) | DRD2HTR1AHTR2AKCNH2SLC6A2 | |
| SCHEMBL11275993 | 0.83 | LMNA (0.67) | DRD2HTR1AHTR2AKCNH2SLC6A2 | |
| SCHEMBL11267243 | 0.81 | DRD2 (0.62) | DRD2HTR1AHTR2AKCNH2SLC6A2 | |
| SCHEMBL11266451 | 0.81 | HRH1 (0.74) | DRD2HTR1AHTR2AKCNH2SLC6A2 | |
| SCHEMBL11278314 | 0.81 | SLC6A4 (0.70) | DRD2SLC6A2SLC6A4HRH1HRH3 | |
| SCHEMBL251586 | 0.81 | DRD2 (0.93) | DRD2HTR1AHTR2AKCNH2SLC6A2 | |
| SCHEMBL11285131 | 0.80 | DRD2 (0.69) | DRD2HTR2ASLC6A2SLC6A4HRH1 | |
| SCHEMBL11270204 | 0.80 | DRD2 (0.53) | DRD2HTR1AHTR2AALDH1A1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4339580-A | TRANQUILIZERS, SEDATIVES | MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) | 1982-07-13 | — | — | US | disclosed |
| EP-0021368-B1 | PIPERAZINYLALKOXYINDANES AND ACID ADDITION SALTS THEREOF | MITSUBISHI KASEI CORPORATION (JP) | 1982-05-19 | — | — | EP | disclosed |
| EP-0021368-A1 | Piperazinylalkoxyindanes and acid addition salts thereof | MITSUBISHI KASEI CORPORATION (JP) | 1981-01-07 | — | — | EP | disclosed |