Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.44 |
| ▸ | BCHE | P06276 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10914047 | 0.87 | HSD11B1 (0.50) | ACHEBCHESMN1; SMN2OPRM1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL10916739 | 0.86 | HSD11B1 (0.49) | ACHEBCHESMN1; SMN2OPRM1SIGMAR1 | |
| SCHEMBL10918399 | 0.81 | CCR2 (0.45) | ACHEBCHESMN1; SMN2DRD4KMT2A | |
| SCHEMBL10971590 | 0.81 | POLB (0.45) | SMN1; SMN2MEN1KMT2ATSHRKDM4E | |
| SCHEMBL10917978 | 0.81 | ALDH1A1 (0.49) | SMN1; SMN2MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL10916248 | 0.80 | ALDH1A1 (0.51) | SMN1; SMN2MEN1KMT2ATSHRKDM4E | |
| SCHEMBL10918979 | 0.79 | ALDH1A1 (0.52) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL10922643 | 0.78 | POLB (0.42) | MEN1KMT2AALDH1A1 | |
| SCHEMBL10920934 | 0.78 | TSHR (0.51) | SMN1; SMN2KMT2ATSHRKDM4EALDH1A1 | |
| SCHEMBL10919669 | 0.76 | NPC1 (0.50) | MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064707-B1 | 4-(4-PHENYL-1-PIPERIDINYL)METHYL-5-ACYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-07-23 | — | — | EP | disclosed |
| EP-0064707-A1 | 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |
| US-4329471-A | CARDIOTONICS, HYPOTENSIVE AGENTS, AND ANTITHROMBOTIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-05-11 | — | — | US | disclosed |