SCHEMBL11267749

SCHEMBL11267749

Cn1c2ccc(Cl)cc2c2oc(C#N)cc(=O)c21

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 1/20 0.35
MCHR1 Q99705 2/20 0.35
KDM4E B2RXH2 3/20 0.34
MAPT P10636 2/20 0.34
HCRTR1 O43613 1/20 0.34
CASP1 P29466 1/20 0.34
CASP7 P55210 1/20 0.34
ALDH1A1 P00352 4/20 0.34
HPGD P15428 3/20 0.34
GAA P10253 2/20 0.34
HSD17B10 Q99714 1/20 0.34
GPR35 Q9HC97 1/20 0.33
GABRA1 P14867 3/20 0.32
GABRG2 P18507 3/20 0.32
GABRB3 P28472 3/20 0.32
GABRA5 P31644 3/20 0.32
BAZ2B Q9UIF8 1/20 0.32
MEN1 O00255 1/20 0.32
LMNA P02545 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11284898 0.86 KDM4E (0.40) RAB9AKDM4EMAPTALDH1A1HPGD
SCHEMBL11269382 0.83 HPGD (0.39) RAB9AKDM4EMAPTALDH1A1HPGD
SCHEMBL11270041 0.77 ALDH1A1 (0.53) KDM4EALDH1A1GPR35KMT2A
SCHEMBL11416700 0.72 MAOB (0.61) KDM4EMAPTCASP1ALDH1A1HPGD
SCHEMBL11273764 0.71 PLK1 (0.33) KDM4EMAPTHCRTR1CASP1CASP7
SCHEMBL6957384 0.70 ADCY1 (0.55) RAB9AKDM4EMAPTALDH1A1HPGD
SCHEMBL29891682 0.70 MCHR1 (0.46) RAB9AMCHR1KDM4EMAPTHCRTR1
SCHEMBL5527743 0.70 MCHR1 (0.46) RAB9AMCHR1KDM4EMAPTHCRTR1
SCHEMBL25389422 0.68 GSK3B (0.45) RAB9AMCHR1KDM4EALDH1A1HPGD
SCHEMBL607256 0.65 PKM (0.44) KDM4EMAPTHCRTR1CASP1CASP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4316904-A Indolopyrone tetrazoles and carboxamidotetrazoles having antiallergic activity WARNER-LAMBERT COMPANY 1982-02-23 US disclosed