Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GPR35 | Q9HC97 | 9/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11274923 | 0.86 | GPR35 (0.43) | GPR35KMT2AMCL1KDM4EUSP2 | |
| SCHEMBL11416700 | 0.83 | MAOB (0.61) | ALDH1A1GPR35MAOBKDM4E | |
| SCHEMBL11278189 | 0.83 | KDM4E (0.50) | ALDH1A1GPR35EGFRKDM4EUSP2 | |
| SCHEMBL11276735 | 0.81 | GPR35 (0.47) | ALDH1A1GPR35KMT2AEGFR | |
| SCHEMBL11273550 | 0.77 | MAPT (0.39) | GPR35MAOBEGFR | |
| SCHEMBL11267749 | 0.77 | RAB9A (0.35) | ALDH1A1GPR35KMT2AKDM4E | |
| SCHEMBL11421772 | 0.75 | MCL1 (0.40) | ALDH1A1KMT2AMCL1OXER1RXFP1 | |
| SCHEMBL11269004 | 0.71 | EGFR (0.43) | ALDH1A1KMT2AEGFRKDM4EUSP2 | |
| SCHEMBL11273764 | 0.71 | PLK1 (0.33) | ALDH1A1KDM4ECSNK2A2CSNK2B | |
| SCHEMBL1504213 | 0.70 | ALDH1A1 (1.00) | ALDH1A1MAOBMCL1KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4188326-A | Indolopyrones having anti-allergic activity | WARNER-LAMBERT COMPANY (US) | 1980-02-12 | — | — | US | claimed |
| US-4316904-A | Indolopyrone tetrazoles and carboxamidotetrazoles having antiallergic activity | WARNER-LAMBERT COMPANY | 1982-02-23 | — | — | US | disclosed |
| US-4188326-A | Indolopyrones having anti-allergic activity | WARNER-LAMBERT COMPANY (US) | 1980-02-12 | — | — | US | disclosed |
| US-4175083-A | ANTIHISTAMINES, ANTIALLERGENS | WARNER-LAMBERT COMPANY (US) | 1979-11-20 | — | — | US | disclosed |
| US-4148806-A | Process for the preparation of indolopyrones | WARNER-LAMBERT COMPANY (US) | 1979-04-10 | — | — | US | disclosed |