SCHEMBL1126854

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1126557	0.86	LMNA (0.39)	GFERSMN1; SMN2RGS12TSHRMAPT
	SCHEMBL1126589	0.83	LMNA (0.39)	GFERSMN1; SMN2RGS12TSHRMAPT
	SCHEMBL1126056	0.82	LMNA (0.42)	GFERSMN1; SMN2TSHRMAPTNPC1
	SCHEMBL1126441	0.82	TSHR (0.38)	GFERSMN1; SMN2RGS12TSHRMAPT
	SCHEMBL1126771	0.81	GFER (0.37)	GFERSMN1; SMN2RGS12TSHRMAPT
	SCHEMBL4444883	0.81	ALDH1A1 (0.46)	GFERSMN1; SMN2TSHRMAPTNPC1
	SCHEMBL1127551	0.81	NPC1 (0.37)	GFERSMN1; SMN2RGS12TSHRMAPT
	SCHEMBL1126825	0.78	LMNA (0.39)	GFERTSHRMAPTUSP2KDM4E
	SCHEMBL1987403	0.77	ALDH1A1 (0.40)	TSHRMAPTUSP2NPSR1KDM4E
	SCHEMBL1126361	0.76	MAPT (0.41)	GFERSMN1; SMN2TSHRMAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.