Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11269128 | 0.90 | CYP1A2 (0.52) | KCNH2SIGMAR1ALDH1A1HTR1A | |
| SCHEMBL11275227 | 0.86 | KCNH2 (0.60) | KCNH2ADRA1DADRA1AADRA1BABCB1 | |
| SCHEMBL11273991 | 0.84 | DRD2 (0.48) | ADRA1DADRA1AADRA1BABCB1SIGMAR1 | |
| SCHEMBL11276248 | 0.84 | KCNH2 (0.57) | KCNH2ADRA1DADRA1AADRA1BABCB1 | |
| SCHEMBL11270171 | 0.84 | KCNH2 (0.57) | KCNH2ADRA1DADRA1AADRA1BABCB1 | |
| SCHEMBL11283459 | 0.84 | KCNH2 (0.60) | KCNH2ABCB1SIGMAR1LMNA | |
| SCHEMBL11300075 | 0.83 | KCNH2 (0.62) | KCNH2ADRA1DADRA1AADRA1BABCB1 | |
| SCHEMBL11276199 | 0.81 | KCNH2 (0.58) | KCNH2ABCB1SIGMAR1HTR7HTR1A | |
| SCHEMBL11282280 | 0.79 | ADRA1D (0.70) | KCNH2ADRA1DADRA1AADRA1BHTR7 | |
| SCHEMBL11275580 | 0.78 | KCNH2 (0.60) | KCNH2ABCB1SIGMAR1HTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0020107-B1 | 3-ALLYL-7,8-DIHYDROXY-6-HALO-1-(4-HYDROXYPHENYL)-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE DERIVATIVES, PROCESS FOR PREPARING THEM AND COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1982-08-11 | — | — | EP | disclosed |
| US-4339580-A | TRANQUILIZERS, SEDATIVES | MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) | 1982-07-13 | — | — | US | disclosed |
| EP-0021368-B1 | PIPERAZINYLALKOXYINDANES AND ACID ADDITION SALTS THEREOF | MITSUBISHI KASEI CORPORATION (JP) | 1982-05-19 | — | — | EP | disclosed |
| EP-0021368-A1 | Piperazinylalkoxyindanes and acid addition salts thereof | MITSUBISHI KASEI CORPORATION (JP) | 1981-01-07 | — | — | EP | disclosed |