SCHEMBL1127205

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL25029268	0.81	KMT2A (0.60)	NOS3NOS2NOS1KMT2ATHRB
	SCHEMBL17127911	0.78	NOS3 (0.41)	NOS3NOS2NOS1KMT2ATHRB
	SCHEMBL17974951	0.78	POLQ (0.48)	NOS3NOS2NOS1KMT2ATHRB
	SCHEMBL942231	0.76	ALDH1A1 (0.47)	NOS3NOS2NOS1KMT2AALDH1A1
	SCHEMBL19007358	0.75	NOS3 (0.39)	NOS3NOS2NOS1KMT2ATHRB
	SCHEMBL28798494	0.75	KMT2A (0.40)	NOS3NOS2NOS1KMT2ATHRB
	SCHEMBL23074667	0.74	ALDH1A1 (0.46)	NOS3NOS2NOS1ALDH1A1LMNA
	SCHEMBL8352772	0.73	LOXL2 (0.46)	NOS3NOS2NOS1KMT2AMEN1
	SCHEMBL5859072	0.73	HTR7 (0.44)	NOS3NOS2
	SCHEMBL1987466	0.72	F2 (0.40)	NOS3NOS2NOS1KMT2APOLQ

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.