Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11263084 | 0.84 | HPGD (0.44) | SIGMAR1P2RX7CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL7239164 | 0.67 | P2RX7 (0.55) | SIGMAR1P2RX7CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13613506 | 0.65 | MEN1 (0.55) | SIGMAR1P2RX7ALDH1A1MAPTMAPK1 | |
| SCHEMBL30798198 | 0.64 | KMT2A (0.57) | SIGMAR1P2RX7ALDH1A1MAPTMAPK1 | |
| SCHEMBL11799876 | 0.64 | ALDH1A1 (0.62) | SIGMAR1P2RX7CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7237400 | 0.64 | P2RX7 (0.46) | SIGMAR1P2RX7CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11269563 | 0.64 | LMNA (0.62) | CYP1A2CYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL10690514 | 0.63 | SIGMAR1 (0.47) | SIGMAR1P2RX7CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7245747 | 0.63 | P2RX7 (0.47) | P2RX7CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL19370620 | 0.62 | DDB1 (0.55) | SIGMAR1P2RX7ALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0019440-B1 | BENZIMIDAZOLONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1982-09-29 | — | — | EP | disclosed |