Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11278589 | 0.78 | HRH3 (0.37) | TSHRHSD17B10 | |
| SCHEMBL25761855 | 0.76 | CASP3 (0.59) | KAT2AKAT2B | |
| SCHEMBL15680602 | 0.75 | ESR1 (0.36) | KAT2AKAT2B | |
| SCHEMBL11407006 | 0.74 | CASP3 (0.59) | KAT2AKAT2B | |
| SCHEMBL11348382 | 0.73 | CASP3 (0.57) | KAT2AKAT2B | |
| Hydrochloric Acid SCHEMBL11272284 | 0.72 | CASP3 (0.56) | KAT2AKAT2B | |
| SCHEMBL11269992 | 0.72 | SIGMAR1 (0.41) | ALDH1A1KDM4EHTTKMT2AMAPT | |
| SCHEMBL11188537 | 0.71 | FAAH (0.68) | ALDH1A1TSHRHSD17B10KAT2AKAT2B | |
| Hydrochloric Acid SCHEMBL11281719 | 0.71 | SIGMAR1 (0.40) | ALDH1A1KDM4EHTTTDP1 | |
| SCHEMBL21996048 | 0.70 | P4HB (0.72) | ALDH1A1KDM4EL3MBTL1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4350702-A | 2-SUBSTITUTED BENZISOTHIAZOLONES | BEECHAM GROUP LIMITED (GB) | 1982-09-21 | — | — | US | disclosed |
| US-4243669-A | ANTICOAGULANTS | BEECHAM GROUP LIMITED (GB) | 1981-01-06 | — | — | US | disclosed |
| US-4212872-A | ANTICOAGULANTS | BEECHAM GROUP LIMITED (GB) | 1980-07-15 | — | — | US | disclosed |
| US-4212979-A | ANTITHROMOGENIC | BEECHAM GROUP LIMITED (GB) | 1980-07-15 | — | — | US | disclosed |
| US-4113728-A | ANTICOAGULANTS | BEECHAM GROUP LIMITED (GB) | 1978-09-12 | — | — | US | disclosed |