SCHEMBL11269992

SCHEMBL11269992

O=c1c2cc(Cl)c(Cl)cc2sn1CCN1CCCC1

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 3/20 0.41
TMEM97 Q5BJF2 3/20 0.39
DRD2 P14416 2/20 0.37
DRD3 P35462 2/20 0.37
HTT P42858 1/20 0.36
ATM Q13315 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
MAPT P10636 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11281719 0.99 SIGMAR1 (0.40) SIGMAR1TMEM97DRD2DRD3HTT
SCHEMBL11268310 0.82 DRD2 (0.38) DRD2DRD3ALDH1A1
SCHEMBL11407006 0.76 CASP3 (0.59)
SCHEMBL11348382 0.75 CASP3 (0.57)
Hydrochloric Acid SCHEMBL11272284 0.73 CASP3 (0.56)
SCHEMBL11463916 0.72 MAOA (0.46) ALDH1A1KMT2A
Oxalic Acid SCHEMBL11273608 0.72 ALDH1A1 (0.46) HTTTDP1KDM4EALDH1A1MAPT
SCHEMBL15680600 0.71 DTYMK (0.39) KDM4EALDH1A1SMN1; SMN2
SCHEMBL11461566 0.70 CASP3 (0.35)
SCHEMBL9829900 0.67 FAAH (0.59)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4350702-A 2-SUBSTITUTED BENZISOTHIAZOLONES BEECHAM GROUP LIMITED (GB) 1982-09-21 US claimed
US-4350702-A 2-SUBSTITUTED BENZISOTHIAZOLONES BEECHAM GROUP LIMITED (GB) 1982-09-21 US disclosed
US-4243669-A ANTICOAGULANTS BEECHAM GROUP LIMITED (GB) 1981-01-06 US disclosed
US-4212872-A ANTICOAGULANTS BEECHAM GROUP LIMITED (GB) 1980-07-15 US disclosed
US-4212979-A ANTITHROMOGENIC BEECHAM GROUP LIMITED (GB) 1980-07-15 US disclosed
US-4113728-A ANTICOAGULANTS BEECHAM GROUP LIMITED (GB) 1978-09-12 US disclosed