Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10492054 | 0.87 | LMNA (0.48) | MAPTALDH1A1SMN1; SMN2TDP1LMNA | |
| Trifluoromethanesulfonic Acid SCHEMBL8736573 | 0.82 | PTPN5 (0.43) | MAPTALDH1A1SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL18574523 | 0.82 | RAB9A (0.46) | MAPTALDH1A1SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL10492070 | 0.80 | ALDH1A1 (0.47) | MAPTALDH1A1SMN1; SMN2TDP1LMNA | |
| SCHEMBL11274305 | 0.80 | CA12 (0.43) | MAPTALDH1A1SMN1; SMN2TDP1LMNA | |
| SCHEMBL28489436 | 0.79 | MAPT (0.43) | MAPTALDH1A1SMN1; SMN2TDP1LMNA | |
| SCHEMBL21730833 | 0.78 | ENPP3 (0.44) | MAPTALDH1A1SMN1; SMN2NPC1NFKB1 | |
| SCHEMBL760070 | 0.78 | MEN1 (0.44) | MAPTALDH1A1SMN1; SMN2TDP1LMNA | |
| SCHEMBL2901950 | 0.78 | ALDH1A1 (0.49) | MAPTALDH1A1SMN1; SMN2TDP1LMNA | |
| SCHEMBL4653600 | 0.77 | PTPN11 (0.47) | MAPTALDH1A1SMN1; SMN2TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4348525-A | LIGAND TRANSFER REACTION | THE UNIVERSITY OF AKRON (US) | 1982-09-07 | — | — | US | disclosed |