Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | ACACB | O00763 | 6/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ACACA | Q13085 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11075541 | 0.94 | LMNA (0.66) | LMNAGAAHTTMMP9MMP8 | |
| SCHEMBL11080051 | 0.87 | PARP10 (0.56) | LMNAGAAHTTACACBPLK1 | |
| SCHEMBL2224153 | 0.85 | SMN1; SMN2 (0.58) | LMNAMMP9MMP8MMP13ACACB | |
| SCHEMBL11083428 | 0.82 | KMT2A (0.52) | LMNAACACBL3MBTL1SMN1; SMN2ACACA | |
| SCHEMBL22504107 | 0.81 | PARP10 (0.50) | LMNAGAAHTTMMP9MMP8 | |
| SCHEMBL11071292 | 0.80 | L3MBTL1 (0.61) | L3MBTL1CA1CA2 | |
| SCHEMBL11079676 | 0.78 | CA12 (0.49) | LMNAHTTACACBL3MBTL1PLK1 | |
| SCHEMBL14437955 | 0.77 | LMNA (0.48) | LMNAGAAHTTMMP9MMP8 | |
| SCHEMBL5327477 | 0.77 | MMP9 (0.62) | LMNAGAAHTTMMP9MMP8 | |
| SCHEMBL18713940 | 0.77 | LTA4H (0.50) | LMNAACACBL3MBTL1PLK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4322421-A | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4261995-A | DISORDERS OF CENTRAL NERVOUS SYSTEM AND CARDIOVASCULAR SYSTEM; HYPOTENSIVE | SYNTEX (U.S.A.) INC. (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |