Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.46 |
| ▸ | MELK | Q14680 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6833866 | 0.92 | CYP19A1 (0.42) | PRKCZCSNK1DCSNK1ECLK1DYRK1A | |
| SCHEMBL29720261 | 0.92 | CYP19A1 (0.42) | PRKCZCSNK1DCSNK1ECLK1DYRK1A | |
| SCHEMBL15941610 | 0.77 | ALDH1A1 (0.38) | — | |
| SCHEMBL1793381 | 0.75 | CYP2A6 (0.38) | CYP2A6 | |
| SCHEMBL692352 | 0.74 | PRKCZ (0.38) | PRKCZMELKCYP19A1TBXAS1IKBKB | |
| SCHEMBL8878299 | 0.73 | CSNK1D (0.38) | CSNK1DCSNK1ECLK1DYRK1ACYP2A6 | |
| SCHEMBL30824503 | 0.72 | CYP2A6 (0.56) | PRKCZMELKCYP19A1TBXAS1IKBKB | |
| SCHEMBL761399 | 0.72 | CYP2A6 (0.56) | PRKCZMELKCYP19A1TBXAS1IKBKB | |
| SCHEMBL24371296 | 0.72 | EGFR (0.53) | PRKCZMELKCYP19A1TBXAS1MAPT | |
| SCHEMBL5952419 | 0.72 | CYP2A6 (0.48) | CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12552830-B2 | Steroidal compound derivatives as therapeutic agents | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2026-02-17 | — | — | US | disclosed |
| US-20240376145-A9 | STEROIDAL COMPOUND DERIVATIVES AS THERAPEUTIC AGENTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2024-11-14 | — | — | US | disclosed |
| US-20240083936-A1 | STEROIDAL COMPOUND DERIVATIVES AS THERAPEUTIC AGENTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2024-03-14 | — | — | US | disclosed |
| WO-2022133265-A1 | STEROIDAL COMPOUND DERIVATIVES AS THERAPEUTIC AGENTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORTED (US) | 2022-06-23 | — | — | WO | disclosed |
| US-10202400-B2 | Cortistatin analogues and syntheses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-02-12 | — | — | US | disclosed |
| US-20170320886-A1 | CORTISTATIN ANALOGUES AND SYNTHESES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-11-09 | — | — | US | disclosed |
| US-9714255-B2 | Cortistatin analogues and syntheses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-07-25 | — | — | US | disclosed |
| US-20150376201-A1 | CORTISTATIN ANALOGUES AND SYNTHESES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-12-31 | — | — | US | disclosed |
| US-9127019-B2 | Cortistatin analogues and synthesis thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-09-08 | — | — | US | disclosed |
| US-20150111921-A1 | CORTISTATIN ANALOGUES AND SYNTHESES THEROF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-04-23 | — | — | US | disclosed |
| WO-2014123900-A1 | ANTI-CANCER AND ANTI-HIV COMPOUNDS | SIRENAS MARINE DISCOVERY (US) | 2014-08-14 | — | — | WO | disclosed |
| US-8642766-B2 | Synthesis of (+) cortistatin A and related compounds | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-02-04 | — | — | US | disclosed |
| EP-2283159-B1 | SYNTHESIS OF (+) CORTISTATIN A AND RELATED COMPOUNDS | SCRIPPS RESEARCH INST (US) | 2013-10-09 | — | — | EP | disclosed |
| US-20110190323-A1 | CORTISTATIN ANALOGUES AND SYNTHESES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-08-04 | — | — | US | disclosed |
| EP-2334686-A2 | CORTISTATIN ANALOGUES AND SYNTHESES THEROF | President and Fellows of Harvard College (US) | 2011-06-22 | — | — | EP | disclosed |
| US-20110060140-A1 | SYNTHESIS OF (+) CORTISTATIN A AND RELATED COMPOUNDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-03-10 | — | — | US | disclosed |
| EP-2283159-A1 | SYNTHESIS OF (+) CORTISTATIN A AND RELATED COMPOUNDS | The Scripps Research Institute (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2010024930-A2 | CORTISTATIN ANALOGUES AND SYNTHESES THEROF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-03-04 | — | — | WO | disclosed |
| WO-2009137337-A1 | STEREOSELECTIVE SYNTHESIS OF 17-α -AND 17-β -ARYL STEROIDAL COMPOUNDS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-11-12 | — | — | WO | disclosed |
| WO-2009137335-A1 | SYNTHESIS OF (+) CORSTISTATIN A AND RELATED COMPOUNDS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150111921-A1 | CORTISTATIN ANALOGUES AND SYNTHESES THEROF | TEK, CTTN, FLT1 | PRKCZ 1484/4885MELK 439/4885CSNK1D 253/4885 |
| US-20110190323-A1 | CORTISTATIN ANALOGUES AND SYNTHESES THEREOF | CTTN, TEK, PROKR1 | PRKCZ 1106/4885MELK 514/4885CSNK1D 170/4885 |
| US-20240083936-A1 | STEROIDAL COMPOUND DERIVATIVES AS THERAPEUTIC AGENTS | PGF, HPGDS, NR5A1 | PRKCZ 2970/4885MELK 1720/4885CSNK1D 1876/4885 |
| US-20110060140-A1 | SYNTHESIS OF (+) CORTISTATIN A AND RELATED COMPOUNDS | CTTN, CIAPIN1, PACSIN2 | PRKCZ 2719/4885MELK 645/4885CSNK1D 425/4885 |
| US-10202400-B2 | Cortistatin analogues and syntheses thereof | CTTN, TEK, FLT1 | PRKCZ 955/4885MELK 352/4885CSNK1D 168/4885 |
| US-20150376201-A1 | CORTISTATIN ANALOGUES AND SYNTHESES THEREOF | CTTN, TEK, FLT1 | PRKCZ 955/4885MELK 352/4885CSNK1D 168/4885 |
| US-12552830-B2 | Steroidal compound derivatives as therapeutic agents | PGF, NR3C2, NR5A1 | PRKCZ 3072/4885MELK 544/4885CSNK1D 215/4885 |
| US-20170320886-A1 | CORTISTATIN ANALOGUES AND SYNTHESES THEREOF | CTTN, TEK, FLT1 | PRKCZ 955/4885MELK 352/4885CSNK1D 168/4885 |
| US-20240376145-A9 | STEROIDAL COMPOUND DERIVATIVES AS THERAPEUTIC AGENTS | PGF, HPGDS, NR5A1 | PRKCZ 2970/4885MELK 1720/4885CSNK1D 1876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.