Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | MELK | Q14680 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9901980 | 0.81 | BDKRB2 (0.35) | CYP2A6LMNA | |
| SCHEMBL1452051 | 0.78 | CYP2A6 (0.42) | HDAC3HDAC1HDAC2TDP1CYP2A6 | |
| SCHEMBL1127906 | 0.74 | PRKCZ (0.46) | PRKCZMELKCYP19A1TBXAS1HASPIN | |
| SCHEMBL658276 | 0.74 | CYP2D6 (0.41) | HDAC3HDAC1HDAC2TDP1L3MBTL1 | |
| SCHEMBL6114785 | 0.72 | CYP19A1 (0.49) | PRKCZMELKCYP19A1TBXAS1HDAC3 | |
| SCHEMBL691201 | 0.72 | ALDH1A1 (0.49) | ALDH1A1HTT | |
| SCHEMBL29851135 | 0.71 | L3MBTL1 (0.49) | CYP19A1HDAC3HDAC1HDAC2TDP1 | |
| SCHEMBL154603 | 0.71 | L3MBTL1 (0.49) | CYP19A1HDAC3HDAC1HDAC2TDP1 | |
| SCHEMBL6114827 | 0.71 | TDP1 (0.53) | CYP19A1TBXAS1TDP1L3MBTL1 | |
| SCHEMBL1983658 | 0.71 | TSHR (0.32) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120190659-A1 | ANGIOGENESIS INHIBITORS | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2012-07-26 | — | — | US | disclosed |
| EP-2421882-A2 | ANGIOGENESIS INHIBITORS | President and Fellows of Harvard College (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010123545-A2 | ANGIOGENESIS INHIBITORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190659-A1 | ANGIOGENESIS INHIBITORS | VEGFA, KDR, FLT1 | PRKCZ 3649/4885MELK 1033/4885CYP19A1 455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.