Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.52 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9781420 | 0.89 | MAPT (0.49) | MAPTLMNANPC1RAB9AMAPK1 | |
| SCHEMBL11758254 | 0.82 | MAPT (0.63) | MAPTLMNANPC1RAB9AMAPK1 | |
| SCHEMBL9781450 | 0.78 | LMNA (0.52) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9733728 | 0.76 | ALDH1A1 (0.51) | LMNASMN1; SMN2KMT2AMEN1CYP1A2 | |
| SCHEMBL6541728 | 0.75 | SMN1; SMN2 (0.72) | MAPTLMNANPC1RAB9AMAPK1 | |
| SCHEMBL28644813 | 0.74 | KMT2A (0.58) | MAPTKMT2AMEN1HCAR3 | |
| SCHEMBL7245174 | 0.74 | NPC1 (0.76) | MAPTLMNANPC1RAB9AMAPK1 | |
| SCHEMBL6707064 | 0.73 | MAPT (0.77) | MAPTLMNANPC1RAB9AMAPK1 | |
| SCHEMBL10575752 | 0.72 | MAPT (0.59) | MAPTLMNANPC1RAB9AMAPK1 | |
| SCHEMBL10575746 | 0.72 | MAPT (0.58) | MAPTLMNANPC1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361563-A | CARDIOTONIC, ANTITHROMBOTIC | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1982-11-30 | — | — | US | disclosed |