Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28126128 | 0.86 | LMNA (0.60) | LMNACRHBPCRHR2MEN1KMT2A | |
| SCHEMBL2555441 | 0.83 | LNPEP (0.42) | LMNAMAPTALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8820375 | 0.81 | MAPT (0.56) | LMNAMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL1263066 | 0.80 | LMNA (0.66) | LMNACRHBPCRHR2MEN1KMT2A | |
| SCHEMBL11283118 | 0.78 | MAPT (0.60) | LMNACRHBPCRHR2MEN1KMT2A | |
| SCHEMBL3440935 | 0.77 | LMNA (0.62) | LMNACRHBPCRHR2MEN1KMT2A | |
| SCHEMBL9781420 | 0.77 | MAPT (0.49) | LMNACRHBPCRHR2MEN1KMT2A | |
| SCHEMBL2720856 | 0.77 | LMNA (0.66) | LMNACRHBPCRHR2MEN1KMT2A | |
| SCHEMBL28443421 | 0.74 | LMNA (0.61) | LMNACRHBPCRHR2MEN1KMT2A | |
| SCHEMBL28126130 | 0.74 | LMNA (0.61) | LMNACRHBPCRHR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026705-A | Benzimidazolylpyridazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-06-25 | — | — | US | disclosed |
| US-4923869-A | INOTROPIC, VASODILATING, AND ANTITHROMBOTIC AGENTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-05-08 | — | — | US | disclosed |
| US-4699909-A | CARDIOTONICS, HYPOTENSIVES AND ANTITHROMBOTICS | DR. KARL THOMAE GMBH (DE) | 1987-10-13 | — | — | US | disclosed |
| US-4616018-A | CARDIOTOINC AGENTS, HYPOTENSIVES, AND ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1986-10-07 | — | — | US | disclosed |
| US-4361563-A | CARDIOTONIC, ANTITHROMBOTIC | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1982-11-30 | — | — | US | disclosed |