Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11283118 | 0.89 | MAPT (0.60) | MAPTKMT2ALMNAHCAR3NPC1 | |
| SCHEMBL9781450 | 0.77 | LMNA (0.52) | MAPTKMT2ALMNAALDH1A1HCAR3 | |
| SCHEMBL6707064 | 0.77 | MAPT (0.77) | MAPTKMT2ALMNAGAAALDH1A1 | |
| SCHEMBL28644813 | 0.74 | KMT2A (0.58) | MAPTKMT2AALDH1A1POLBHCAR3 | |
| SCHEMBL8820375 | 0.71 | MAPT (0.56) | MAPTKMT2ALMNAGAAALDH1A1 | |
| SCHEMBL14453683 | 0.71 | KCNMA1 (0.63) | MAPTKMT2ALMNAGAAALDH1A1 | |
| SCHEMBL11758254 | 0.70 | MAPT (0.63) | MAPTKMT2ALMNAALDH1A1POLB | |
| SCHEMBL6462358 | 0.70 | HCAR3 (0.68) | MAPTKMT2ALMNAALDH1A1HCAR3 | |
| SCHEMBL16592660 | 0.68 | HTT (0.66) | MAPTKMT2AGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL9197268 | 0.68 | KMT2A (0.62) | MAPTKMT2ALMNAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026705-A | Benzimidazolylpyridazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-06-25 | — | — | US | disclosed |
| US-4923869-A | INOTROPIC, VASODILATING, AND ANTITHROMBOTIC AGENTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-05-08 | — | — | US | disclosed |