SCHEMBL11285155

SCHEMBL11285155

CSN1C(=O)C(=C2c3ccccc3-c3c(C#N)cc(C#N)cc32)C(=O)N(SC)C1=O

nearest known ligand 0.33

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PGR P06401 1/20 0.33
USP8 P40818 1/20 0.33
USP7 Q93009 1/20 0.33
CASP3 P42574 1/20 0.32
STK10 O94804 1/20 0.31
CLK2 P49760 1/20 0.31
GSK3A P49840 1/20 0.31
GSK3B P49841 1/20 0.31
SLK Q9H2G2 1/20 0.31
CLK4 Q9HAZ1 1/20 0.31
NR1H3 Q13133 1/20 0.30
LMNA P02545 1/20 0.30
TP53 P04637 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11278169 0.92 CASP3 (0.36) CASP3
SCHEMBL11287713 0.87 PGR (0.32) PGRUSP8USP7CASP3LMNA
SCHEMBL11285530 0.79 CASP3 (0.34) CASP3
SCHEMBL11285147 0.79 CASP3 (0.38) PGRUSP8USP7CASP3STK10
SCHEMBL11282573 0.78 CASP3 (0.31) CASP3
SCHEMBL11285537 0.77 CDC25B (0.36) CASP3LMNAMAPT
SCHEMBL11287708 0.76 ALDH1A1 (0.36) PGRUSP8USP7LMNAMAPT
SCHEMBL11280464 0.74 MEN1 (0.32) STK10CLK2GSK3AGSK3BSLK
SCHEMBL11278160 0.71 CASP3 (0.43) CASP3
SCHEMBL11285507 0.69 MEN1 (0.39) NR1H3MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4349618-A 5-DIPHENYLMETHYLENE- OR 5-(FLUOREN-9-YLIDENE) THIOBARBITURIC ACID AND DERIVATIVES AS SENSITIZERS FOR N-VVINYLCARBAZOLE POLYMERS; ELECTROPHORESIS FUJI PHOTO FILM CO., LTD. (JP) 1982-09-14 US disclosed