Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.46 |
| ▸ | SI | P14410 | 1/20 | 0.46 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585676 | 0.89 | ALDH1A1 (0.54) | ALDH1A1TRPA1GAAMGAMSI | |
| SCHEMBL6276955 | 0.84 | ALDH1A1 (0.50) | ALDH1A1TRPA1GAAMGAMSI | |
| SCHEMBL6584152 | 0.83 | L3MBTL1 (0.47) | ALDH1A1TRPA1GAAMGAMSI | |
| SCHEMBL27953522 | 0.81 | ALDH1A1 (0.46) | ALDH1A1TRPA1GAAMGAMSI | |
| SCHEMBL852674 | 0.81 | ALDH1A1 (0.46) | ALDH1A1TRPA1GAAMGAMSI | |
| SCHEMBL5922952 | 0.80 | ALDH1A1 (0.47) | ALDH1A1TRPA1GAAMGAMSI | |
| SCHEMBL2321958 | 0.79 | — | — | |
| SCHEMBL2907286 | 0.79 | ALDH1A1 (0.45) | ALDH1A1TRPA1GAAMGAMSI | |
| SCHEMBL2907288 | 0.79 | ALDH1A1 (0.45) | ALDH1A1TRPA1GAAMGAMSI | |
| SCHEMBL1405832 | 0.78 | ALDH1A1 (0.54) | ALDH1A1TRPA1GAAMGAMSI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250270215-A1 | IMIDAZOLE DERIVATIVES AS ALK5 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2025-08-28 | — | — | US | disclosed |
| EP-4514802-A1 | IMIDAZOLE DERIVATIVES AS ALK5 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2025-03-05 | — | — | EP | disclosed |
| CN-117343220-A | Method for preparing brominated polystyrene by high-stability liquid bromine method | 潍坊鑫洋化工有限公司 | 2024-01-05 | — | — | CN | disclosed |
| US-11858946-B2 | Small molecules active against gram-negative bacteria | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2024-01-02 | — | — | US | disclosed |
| US-11858946-B2 | Small molecules active against gram-negative bacteria | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2024-01-02 | — | — | US | disclosed |
| WO-2023208986-A1 | IMIDAZOLE DERIVATIVES AS ALK5 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2023-11-02 | — | — | WO | disclosed |
| US-20220112203-A1 | SMALL MOLECULES ACTIVE AGAINST GRAM-NEGATIVE BACTERIA | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2022-04-14 | — | — | US | disclosed |
| US-10995097-B2 | Small molecules active against gram-negative bacteria | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2021-05-04 | — | — | US | disclosed |
| US-20190135821-A1 | SMALL MOLECULES ACTIVE AGAINST GRAM-NEGATIVE BACTERIA | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2019-05-09 | — | — | US | disclosed |
| WO-2017156519-A1 | SMALL-MOLECULES ACTIVE AGAINST GRAM-NEGATIVE BACTERIA | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2017-09-14 | — | — | WO | disclosed |
| US-4316025-A | STABVILIZERS FOR POLYMERS | CHIMOSA CHIMICA ORGANICA S.P.A. (IT) | 1982-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10995097-B2 | Small molecules active against gram-negative bacteria | PGLS, MRPL21, CLPP | ALDH1A1 3613/4885TRPA1 3309/4885GAA 51/4885 |
| US-20220112203-A1 | SMALL MOLECULES ACTIVE AGAINST GRAM-NEGATIVE BACTERIA | PGLS, MRPL21, CLPP | ALDH1A1 3814/4885TRPA1 3455/4885GAA 75/4885 |
| US-11858946-B2 | Small molecules active against gram-negative bacteria | PGLS, MRPL21, CLPP | ALDH1A1 3814/4885TRPA1 3455/4885GAA 75/4885 |
| US-20250270215-A1 | IMIDAZOLE DERIVATIVES AS ALK5 INHIBITORS | ALK, TGFBR1, TGFBR2 | ALDH1A1 828/4885TRPA1 2712/4885GAA 778/4885 |
| US-20190135821-A1 | SMALL MOLECULES ACTIVE AGAINST GRAM-NEGATIVE BACTERIA | PGLS, MRPL21, CLPP | ALDH1A1 3613/4885TRPA1 3309/4885GAA 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.