Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | KCNN4 | O15554 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL28828219 | 0.91 | TSHR (0.52) | TSHRCYP1A2KCNN4ALDH1A1MAPK1 | |
| SCHEMBL7619119 | 0.82 | TSHR (0.37) | TSHRMAPK1 | |
| SCHEMBL4448673 | 0.80 | TSHR (0.61) | TSHRCYP1A2KCNN4ALDH1A1MAPK1 | |
| SCHEMBL21831068 | 0.80 | TSHR (0.61) | TSHRCYP1A2KCNN4ALDH1A1MAPK1 | |
| Fluoride SCHEMBL28084339 | 0.80 | TSHR (0.93) | TSHRCYP1A2KCNN4ALDH1A1MAPK1 | |
| SCHEMBL5199180 | 0.78 | TSHR (0.58) | TSHRCYP1A2KCNN4ALDH1A1MAPK1 | |
| SCHEMBL345828 | 0.78 | KCNN4 (0.58) | TSHRCYP1A2KCNN4ALDH1A1MAPK1 | |
| SCHEMBL10940043 | 0.76 | TSHR (0.65) | TSHRCYP1A2KCNN4ALDH1A1MAPK1 | |
| SCHEMBL151981 | 0.76 | TSHR (0.65) | TSHRCYP1A2KCNN4ALDH1A1MAPK1 | |
| Chlorotriphenylmethane SCHEMBL461 | 0.76 | TSHR (0.65) | TSHRCYP1A2KCNN4ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115784972-A | Ethylene diamine derivative and preparation method and application thereof | 江苏普莱医药生物技术有限公司 | 2023-03-14 | — | — | CN | claimed |
| EP-1773934-A2 | NOVEL FIRE RETARDANTS | Bromine Compounds Ltd. (IL) | 2007-04-18 | — | — | EP | claimed |
| WO-2006006154-A2 | NOVEL FIRE RETARDANTS | BROMINE COMPOUNDS LTD. (IL) | 2006-01-19 | — | — | WO | claimed |
| CN-114181207-B | Beta-carboline compounds, preparation method thereof and application thereof in resisting Alzheimer disease | 中国人民解放军北部战区总医院 | 2022-12-13 | — | — | CN | disclosed |
| CN-114975904-A | Polyoxometalate-based viologen polymer derived carbide composite material and preparation method and application thereof | 上海应用技术大学 | 2022-08-30 | — | — | CN | disclosed |
| WO-2022123530-A1 | BORONIC ACID COMPOUND | 주식회사 엘지화학 | 2022-06-16 | — | — | WO | disclosed |
| CN-103709094-B | 4-phenoxy benzamide compounds and its preparation method and application | XIAMEN UNIVERSITY (CN) | 2016-04-06 | — | — | CN | disclosed |
| EP-2262785-B1 | BENZOFURANE DERIVATIVES AS FXR MODULATORS | MERCK PATENT GMBH (DE) | 2015-01-14 | — | — | EP | disclosed |
| CN-103709094-A | 4-phenoxy benzamide compound as well as preparation method and application thereof | UNIV XIAMEN | 2014-04-09 | — | — | CN | disclosed |
| US-8575161-B2 | Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators | MERCK PATENT GMBH (DE) | 2013-11-05 | — | — | US | disclosed |
| US-20110105475-A1 | BENZOFURANE, BENZOTHIOPHENE, BENZOTHIAZOL DERIVATIVES AS FXR MODULATORS | MERXCK PATENT GESELLSCHAFT (DE) | 2011-05-05 | — | — | US | disclosed |
| WO-1998054207-A1 | ANTI-INFLAMMATORY TYROSINE DERIVATIVES | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-12-03 | — | — | WO | disclosed |
| US-5234917-A | Hypotensive agent, treatment of renal failure or glaucoma | SMITHKLINE BEECHAM CORPORATION | 1993-08-10 | — | — | US | disclosed |
| US-4876376-A | Process for the halogenation, nitration and fluorination of aromatic derivatives | RHONE-POULENC SPECIALISTES CHIMIQUES (FR) | 1989-10-24 | — | — | US | disclosed |
| EP-0130876-B1 | PROCESS FOR THE SIMULTANEOUS HALOGENATION AND FLUORINATION OF AROMATIC COMPOUNDS | RHONE-POULENC CHIMIE (FR) | 1988-04-20 | — | — | EP | disclosed |
| EP-0130875-B1 | PROCESS FOR THE HALOGENATION-NITRATION FLUORINATION OF AROMATIC COMPOUNDS | RHONE-POULENC CHIMIE (FR) | 1987-07-22 | — | — | EP | disclosed |
| EP-0220810-A1 | Insecticidal ethers | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-05-06 | — | — | EP | disclosed |
| US-4575571-A | HALOGEN IN LIQUID HYDROGEN FLUORIDE | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1986-03-11 | — | — | US | disclosed |
| EP-0130876-A1 | Process for the simultaneous halogenation and fluorination of aromatic compounds | RHONE-POULENC CHIMIE (FR) | 1985-01-09 | — | — | EP | disclosed |
| EP-0130875-A1 | Process for the halogenation-nitration fluorination of aromatic compounds | RHONE-POULENC CHIMIE (FR) | 1985-01-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105475-A1 | BENZOFURANE, BENZOTHIOPHENE, BENZOTHIAZOL DERIVATIVES AS FXR MODULATORS | FXR1, FXR2, NR1H4 | TSHR 1235/4885CYP1A2 65/4885KCNN4 3768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.