Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KDM6B | O15054 | 10/20 | 0.50 |
| ▸ | KDM4A | O75164 | 10/20 | 0.50 |
| ▸ | KDM4D | Q6B0I6 | 10/20 | 0.50 |
| ▸ | HIF1AN | Q9NWT6 | 10/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 10/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 8/20 | 0.50 |
| ▸ | KDM3B | Q7LBC6 | 8/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10561964 | 0.77 | KDM6B (0.74) | ALDH1A1KDM4EMAPK1KDM6BKDM4A | |
| SCHEMBL20060568 | 0.73 | MAPK1 (0.61) | ALDH1A1KDM4EMAPK1KDM6BKDM4A | |
| SCHEMBL6813662 | 0.67 | KDM4E (0.43) | ALDH1A1KDM4EMAPK1KDM6BKDM4A | |
| SCHEMBL26288583 | 0.64 | LMNA (0.53) | ALDH1A1KDM4EMAPK1KDM6BKDM4A | |
| SCHEMBL9570985 | 0.64 | PARP1 (0.38) | KDM4EPOLBLMNADAO | |
| SCHEMBL11900387 | 0.63 | LMNA (0.59) | ALDH1A1KDM4EMAPK1KDM6BKDM4A | |
| SCHEMBL9571043 | 0.63 | MAPT (0.40) | ALDH1A1KDM4EKDM6BKDM4AKDM4D | |
| SCHEMBL14485931 | 0.62 | DAO (0.55) | ALDH1A1KDM4EKDM6BKDM4AKDM4D | |
| SCHEMBL26039915 | 0.62 | KDM6B (0.65) | ALDH1A1KDM4EKDM6BKDM4AKDM4D | |
| SCHEMBL26063190 | 0.62 | ALDH1A1 (0.45) | ALDH1A1KDM4EMAPK1KDM6BKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0004279-B1 | PROCESS FOR THE PREPARATION OF 4-PYRIDONE-3-CARBOXYLIC ACIDS, 1-CYCLOPROPYL-4-PYRIDONE-3-CARBOXYLIC ACID DERIVATIVES AND MEDICINES CONTAINING THEM | BAYER AG (DE) | 1982-12-29 | — | — | EP | disclosed |