Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11301410 | 0.87 | HDAC6 (0.47) | L3MBTL1GAAHDAC6TNKSTNKS2 | |
| SCHEMBL11301393 | 0.83 | ALOX15 (0.56) | ALDH1A1HTTALOX15MAPTGAA | |
| SCHEMBL11296506 | 0.80 | ALOX15 (0.44) | ALDH1A1HTTALOX15L3MBTL1KDM4E | |
| SCHEMBL11296058 | 0.80 | MEN1 (0.47) | ALDH1A1HTTMAPTL3MBTL1GAA | |
| SCHEMBL11299441 | 0.77 | MAPK14 (0.37) | MAPTL3MBTL1GAAKDM4EMEN1 | |
| SCHEMBL11295039 | 0.77 | PSEN1 (0.40) | GAAKMT2ALMNASMN1; SMN2TSHR | |
| SCHEMBL28283538 | 0.76 | ALDH1A1 (0.54) | ALDH1A1HTTALOX15EGLN1SLC40A1 | |
| SCHEMBL11296615 | 0.75 | FLT1 (0.38) | MAPTMEN1KMT2A | |
| SCHEMBL11304990 | 0.72 | HDAC6 (0.48) | ALDH1A1L3MBTL1MEN1KMT2AHDAC6 | |
| SCHEMBL11301790 | 0.67 | HDAC6 (0.36) | ALOX15KDM4EMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665706-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012098132-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |