SCHEMBL1130280

SCHEMBL1130280

C=C(C)C(=O)OCCS(=O)(=O)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.47
HSD11B1 P28845 6/20 0.45
POLB P06746 2/20 0.43
APEX1 P27695 1/20 0.43
HTT P42858 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
PSIP1 O75475 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.42
LMNA P02545 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.41
CA2 P00918 1/20 0.41
THRB P10828 1/20 0.41
TSHR P16473 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29323751 0.91 POLB (0.51) MAPTHSD11B1POLBAPEX1HTT
SCHEMBL9555297 0.86 KMT2A (0.48) MAPTPOLBAPEX1HTTTDP1
SCHEMBL8896484 0.86 ALDH1A1 (0.50) LMNACA2
SCHEMBL28023725 0.85 MAPT (0.50) MAPTHSD11B1POLBHTTPSIP1
SCHEMBL29323726 0.85 ALDH1A1 (0.41) MAPTPOLBAPEX1HTTTDP1
SCHEMBL29323683 0.84 HSD11B1 (0.45) MAPTHSD11B1POLBHTTPSIP1
SCHEMBL13604258 0.84 PSIP1 (0.46) MAPTHSD11B1POLBAPEX1HTT
SCHEMBL24390169 0.84 HSD11B1 (0.46) HSD11B1POLBAPEX1HTTTDP1
SCHEMBL12237322 0.83 CA2 (0.53) MAPTHSD11B1POLBHTTPSIP1
SCHEMBL11793653 0.83 TSHR (0.52) MAPTHSD11B1POLBAPEX1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6559198-B2 A contact lens comprising a copolymer consisting essentially of from about 25 to about 60 weight percent of a ethylenically unsaturated fluorosulfone ester monomer having the general formula comonomer selected from the group consisting of NOVICKY NICK (CA) 2003-05-06 US claimed
US-20030027886-A1 Fluorocarbon-sulfone hydrophilic contact lenses, optical medical devices and compositions thereof NOVICKY NICK (CA) 2003-02-06 US claimed
EP-0231572-B1 Silicone-sulfone and silicone-fluorocarbon-sulfone gas permeable contact lenses and compositions thereof PROGRESSIVE OPTICAL RES LTD (CA) 1994-11-02 EP claimed
US-4748224-A Silicone-sulfone and silicone-fluorocarbon-sulfone gas permeable contact lenses and compositions thereof Devou, Maureen J. (CA) 1988-05-31 US claimed
EP-0231572-A2 Silicone-sulfone and silicone-fluorocarbon-sulfone gas permeable contact lenses and compositions thereof PROGRESSIVE OPTICAL RESEARCH LTD. (CA) 1987-08-12 EP claimed
US-11957928-B1 Friction-based therapeutic light penile device Flow State IP LLC (US) 2024-04-16 US disclosed
WO-2023190981-A1 GLASS PRODUCT FOR RESIN COMPOSITE MATERIALS 日本板硝子株式会社 2023-10-05 WO disclosed
EP-3600806-B1 TRANSPARENT WOOD AND A METHOD FOR ITS PREPARATION CELLUTECH AB (SE) 2023-06-07 EP disclosed
US-11602872-B2 Transparent wood and a method for its preparation CELLUTECH AB (SE) 2023-03-14 US disclosed
US-20220183818-A1 DEVICE AND ASSEMBLIES FOR ORIENTED TRANSPORT, MICROSCOPIC INVESTIGATION AND ORIENTED EJECTION OF A TISSUE GRAFT OR IMPLANT TISSUEGUARD GMBH (DE) 2022-06-16 US disclosed
EP-3698758-A1 DEVICE AND ASSEMBLIES FOR ORIENTED TRANSPORT, MICROSCOPIC INVESTIGATION AND ORIENTED EJECTION OF A TISSUE GRAFT OR IMPLANT Leibniz-Institut für Polymerforschung Dresden e.V. (DE) 2020-08-26 EP disclosed
EP-3600806-A1 TRANSPARENT WOOD AND A METHOD FOR ITS PREPARATION Cellutech AB (SE) 2020-02-05 EP disclosed
EP-0515401-A1 ENDLESS OBJECTS FROM ACRYLATES DSM N.V. (NL) 1992-12-02 EP disclosed
US-5093447-A Contact lenses NOVICKY NICK N (CA) 1992-03-03 US disclosed
WO-1991011489-A1 ENDLESS OBJECTS FROM ACRYLATES DSM N.V. (NL) 1991-08-08 WO disclosed
US-4948855-A COPOLYMER OF UNSATURATED SILOXANYLALKOXYESTER AND VINYL SILFONE PROGRESSIVE CHEMICAL RESEARCH, LTD. (CA) 1990-08-14 US disclosed
US-4861850-A CONTACT LENSES PROGRESSIVE CHEMICAL RESEARCH, LTD. (CA) 1989-08-29 US disclosed
US-4748224-A Silicone-sulfone and silicone-fluorocarbon-sulfone gas permeable contact lenses and compositions thereof Devou, Maureen J. (CA) 1988-05-31 US disclosed
US-4743106-A POLYMER HAVING AN ORGANOSILOXANYLALKOXY ESTER OF (METH)ACRYLIC ACID MONOMER; MACHINING Devou, Maureen J. (CA) 1988-05-10 US disclosed
EP-0231572-A2 Silicone-sulfone and silicone-fluorocarbon-sulfone gas permeable contact lenses and compositions thereof PROGRESSIVE OPTICAL RESEARCH LTD. (CA) 1987-08-12 EP disclosed