Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11288193 | 0.90 | MAPT (0.41) | MAPTSMN1; SMN2GAAALDH1A1MEN1 | |
| Bromide SCHEMBL11311515 | 0.70 | INSR (0.39) | MAPTSMN1; SMN2CYP1A2CYP2C19GAA | |
| Bromide SCHEMBL10978694 | 0.67 | ALDH1A1 (0.42) | MAPTSMN1; SMN2GAAALDH1A1MEN1 | |
| Bromide SCHEMBL10974485 | 0.60 | ALDH1A1 (0.43) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| Bromide SCHEMBL10972265 | 0.60 | — | — | |
| Hydrochloric Acid SCHEMBL10973741 | 0.60 | RAB9A (0.33) | SMN1; SMN2ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL23812525 | 0.58 | GAA (0.84) | MAPTSMN1; SMN2CYP1A2CYP2C19GAA | |
| SCHEMBL1276402 | 0.58 | GAA (0.84) | MAPTSMN1; SMN2CYP1A2CYP2C19GAA | |
| SCHEMBL14360821 | 0.57 | ALDH1A1 (0.70) | MAPTSMN1; SMN2CYP1A2CYP2C19GAA | |
| SCHEMBL11545867 | 0.56 | GAA (1.00) | MAPTSMN1; SMN2CYP1A2CYP2C19GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4306016-A | HETEROCYCLIC CYANINE DYE-LIKE NUCLEATING AGENTS | EASTMAN KODAK COMPANY (US) | 1981-12-15 | — | — | US | disclosed |