SCHEMBL1131729

SCHEMBL1131729

CCCCC1=NC2(CCCC2)C(=O)O1

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ACHE P22303 7/20 0.39
ALDH1A1 P00352 2/20 0.36
CYP3A4 P08684 1/20 0.36
PTPN1 P18031 1/20 0.34
ACP1 P24666 1/20 0.34
CDC25B P30305 1/20 0.34
CRHBP P24387 1/20 0.34
HTT P42858 1/20 0.34
CRHR2 Q13324 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
AGTR1 P30556 2/20 0.32
LTB4R2 Q9NPC1 2/20 0.32
CNR1 P21554 1/20 0.32
CNR2 P34972 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1841249 0.88 ALDH1A1 (0.36) ACHEALDH1A1CYP3A4
SCHEMBL9526661 0.88 ALDH1A1 (0.38) ALDH1A1CYP3A4
SCHEMBL19790062 0.81 ALDH1A1 (0.38) ALDH1A1CYP3A4
SCHEMBL1837556 0.78 SMN1; SMN2 (0.36) ALDH1A1CYP3A4HTTNPSR1
SCHEMBL7220404 0.74 CDC25A (0.33) ACHEALDH1A1CDC25B
SCHEMBL19790037 0.72 ALDH1A1 (0.37) ALDH1A1CYP3A4
SCHEMBL1838114 0.72 ALDH1A1 (0.39) ALDH1A1CYP3A4
SCHEMBL9863514 0.71 ALDH1A1 (0.36) ALDH1A1CYP3A4
SCHEMBL2494925 0.70 CDC25B (0.33) ALDH1A1PTPN1ACP1CDC25B
SCHEMBL1841614 0.69 KCNJ1 (0.33) ALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007052301-A2 PROCESS FOR THE PREPARATION OF IRBESARTAN ALEMBIC LIMITED (IN) 2007-05-10 WO claimed
EP-1919469-B1 PROCESS FOR PREPARING AN ANGIOTENSIN II RECEPTOR ANTAGONIST FARMAPROJECTS S A (ES) 2011-02-16 EP disclosed
EP-1919469-B1 PROCESS FOR PREPARING AN ANGIOTENSIN II RECEPTOR ANTAGONIST FARMAPROJECTS S A (ES) 2011-02-16 EP disclosed
EP-2194050-A1 A new process for the preparation of irbesartan KRKA, tovarna zdravil, d.d., Novo mesto (SI) 2010-06-09 EP disclosed
US-20080281097-A1 Process for Preparing an Angiotensin II Receptor Antagonist FARMAPROJECTS, S. A. (ES) 2008-11-13 US disclosed
US-20080281097-A1 Process for Preparing an Angiotensin II Receptor Antagonist FARMAPROJECTS, S. A. (ES) 2008-11-13 US disclosed
US-20080281097-A1 Process for Preparing an Angiotensin II Receptor Antagonist FARMAPROJECTS, S. A. (ES) 2008-11-13 US disclosed
EP-1919469-A2 PROCESS FOR PREPARING AN ANGIOTENSIN II RECEPTOR ANTAGONIST Farmaprojects, S.A. (ES) 2008-05-14 EP disclosed
WO-2007052301-A3 PROCESS FOR THE PREPARATION OF IRBESARTAN ALEMBIC LTD (IN) 2007-07-12 WO disclosed
WO-2007052301-A2 PROCESS FOR THE PREPARATION OF IRBESARTAN ALEMBIC LIMITED (IN) 2007-05-10 WO disclosed
WO-2007052301-A2 PROCESS FOR THE PREPARATION OF IRBESARTAN ALEMBIC LIMITED (IN) 2007-05-10 WO disclosed
WO-2007017469-A2 PROCESS FOR PREPARING AN ANGIOTENSIN II RECEPTOR ANTAGONIST FARMAPROJECTS, S. A. (ES) 2007-02-15 WO disclosed
WO-2007017469-A2 PROCESS FOR PREPARING AN ANGIOTENSIN II RECEPTOR ANTAGONIST FARMAPROJECTS, S. A. (ES) 2007-02-15 WO disclosed
EP-1749828-A1 Process for preparing an angiotensin II receptor antagonist FARMAPROJECTS S.L. (ES) 2007-02-07 EP disclosed
EP-1749828-A1 Process for preparing an angiotensin II receptor antagonist FARMAPROJECTS S.L. (ES) 2007-02-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080281097-A1 Process for Preparing an Angiotensin II Receptor Antagonist AGTR2, AGTR1, REN ACHE 4719/4885ALDH1A1 1267/4885CYP3A4 662/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.